Evidence map›Paper›PMID 26049956›Full record

ReviewCurrent opinion in HIV and AIDS2015

Planning ahead for implementation of long-acting HIV prevention: challenges and opportunities.

Kathrine Meyers, Sarit A Golub

Abstract readReview
In one paragraph

Review in Current opinion in HIV and AIDS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kathrine MeyersaAaron Diamond AIDS Research Center, New York, New York, USA bHunter College of the City University of New York.
Sarit A Golub

Funding

Understanding Implementation of HIV Prevention Navigation in STD ClinicsR01MH106380 · NIMH · HUNTER COLLEGE · PI GOLUB, SARIT A · 2015 to 2019
$4.0M
Intervention to Enhance PrEP Uptake and Adherence in a Community-Based SettingR01AA022067 · NIAAA · HUNTER COLLEGE · PI GOLUB, SARIT A · 2012 to 2016
$3.3M
NIAAA NIH HHS R01 AA022067NIAAA NIH HHS R01AA022067NIMH NIH HHS R01MH105269NIMH NIH HHS R01 MH106380
6 · The paper itself

Abstract

purpose of reviewBroad-based access, uptake, and dissemination of daily oral HIV preexposure prophylaxis (PrEP) have been slow, despite strong evidence for efficacy. Effective and efficient implementation of long-acting HIV prevention products will require both analysis of the dynamics and determinants of daily oral PrEP implementation and identification of the distinct challenges and opportunities inherent in emerging technologies. RECENT

findingsEvidence suggests the importance of addressing implementation issues at three levels: patient, provider, and system. Patient-level factors include targeted education and messaging, tailored supports to enhance acceptability and uptake, and effective strategies for promoting adherence/persistence and retention in care. Provider-level factors include engaging a broad mix of providers, while ensuring adequate training and support for patient assessment, counseling, and follow-up. Systems-level factors include optimal delivery modalities, resource allocation, and ensuring access to populations most in need of new prevention options. SUMMARY: Formative social/behavioral research must be undertaken proactively to prepare for and address future implementation challenges and reduce the gap between proving efficacy in clinical trials and assuring real-world effectiveness. Conceptualizing new HIV prevention technologies as behavioral interventions at the level of the patient, provider, and system will be paramount to effective and efficient implementation.

Indexed as

Anti-Retroviral AgentsBiomedical ResearchDelivery of Health Care, IntegratedHIV InfectionsHumansPatient Acceptance of Health CarePre-Exposure ProphylaxisSocial BehaviorAnti-Retroviral Agents

Identifiers

PMID26049956
PMCPMC4620059

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.