Evidence map›Paper›PMID 26049691›Full record

SynthesisCancer journal (Sudbury, Mass.)

Prevalence of Human Papillomavirus in Oropharyngeal Cancer: A Systematic Review.

Andrew P Stein, Sandeep Saha, Jennifer L Kraninger, Adam D Swick, Menggang Yu, Paul F Lambert, Randall J Kimple

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer journal (Sudbury, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 6 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 6 syntheses or guidelines pooled it, 223 citations in OpenAlex.

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  17. Journal of virology · 2026
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76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrew P SteinFrom the Departments of *Human Oncology, University of Wisconsin Carbone Cancer Center, Madison, WI; †Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI; and ‡Biostatistics, University of Wisconsin, Madison, WI.
Sandeep Saha
Jennifer L Kraninger
Adam D Swick
Menggang Yu
Paul F Lambert
Randall J Kimple
University of Wisconsin–Madison · US

Funding

Visualizing EBV and HCMV DNA Dynamics During InfectionP01CA022443 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F. Lambert · 1985 to 2026
$53.1M
Molecular and Theraputic Studies on HPV-associated Anal CancerR01CA171873 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI LAMBERT, PAUL F. · 2013 to 2016
$1.2M
Head and Neck squamous cell carcinoma radiation response modulation by HPVR00CA160639 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KIMPLE, RANDALL J. · 2013 to 2015
$725k
Head and Neck squamous cell carcinoma radiation response modulation by HPVK99CA160639 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KIMPLE, RANDALL J. · 2011 to 2012
$298k
NCI NIH HHS CA022443NCI NIH HHS CA160639NCI NIH HHS K99 CA160639NCI NIH HHS P01 CA022443NCI NIH HHS R00 CA160639NCI NIH HHS R01 CA171873
6 · The paper itself

Abstract

purposeThe global incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been increasing, and it has been proposed that a rising rate of human papillomavirus (HPV)-associated cancers is driving the observed changes in OPSCC incidence. We carried out this systematic review to further examine the prevalence of HPV in OPSCC over time worldwide.

methodsA systematic literature search was performed to identify all articles through January 31, 2014, which reported on the prevalence of HPV in OPSCC. Articles that met the inclusion criteria were divided into 4 time frames (pre-1995, 1995-1999, 2000-2004, and 2005 to present) based on the median year of the study's sample collection period. Using a weighted analysis of variance model, we examined the trends of HPV-positivity over time worldwide, in North America, and in Europe.

resultsOur literature search identified 699 unique articles. One hundred seventy-five underwent review of the entire study, and 105 met the inclusion criteria. These 105 articles reported on the HPV prevalence in 9541 OPSCC specimens across 23 nations. We demonstrated significant increases in the percentage change of HPV-positive OPSCCs from pre-1995 to present: 20.6% worldwide (P for trend: P < 0.001), 21.6% in North America (P = 0.013), and 21.5% in Europe (P = 0.033).

conclusionsInterestingly, whereas in Europe there was a steady increase in HPV prevalence across all time frames, reaching nearly 50% most recently, in North America HPV prevalence appears to have plateaued over the past decade at about 65%. These findings may have important implications regarding predictions for the future incidence of OPSCC.

Indexed as

Carcinoma, Squamous CellHumansOropharyngeal NeoplasmsPapillomaviridaePapillomavirus InfectionsPrognosis

Identifiers

PMID26049691
PMCPMC4459520
OpenAlexW586307787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.