ReviewDiabetologia2015
Fructose and uric acid in diabetic nephropathy.
Review in Diabetologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 61 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 DiabetesL a Open-label Trial
The Effect of Acute Fructose Load in Patients With Chronic Kidney Disease and Patients With Type 2 Diabetes Compared to Healthy Subjects
Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 As Biomarkers of Acute Kidney Injury in Children With Diabetic Ketoacidosis
Who cites it
61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Hyperuricemia Is Associated With the Risk of Atrial Fibrillation Independent of Sex: A Dose-Response Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Serum Uric Acid and the Risk of Dementia: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- Uric acid in CKD: has the jury come to the verdict?Journal of nephrology · 2020Pooled it
- Effect of immediate and prolonged GLP-1 receptor agonist administration on uric acid and kidney clearance: Post-hoc analyses of four clinical trials.Diabetes, obesity & metabolism · 2018Trial
- Developing and validating a clinlabomics-based machine-learning model for early detection of occult diabetic kidney disease: implications for primary care screening.Frontiers in endocrinology · 2026Article
- The role of advanced glycation end products between thyroid function and diabetic nephropathy and metabolic disorders.Scientific reports · 2025Article
- Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and mortality among survivors of liver cirrhosis: a prospective cohort study.Nutrition journal · 2025Article
- Multi-feature integrated machine learning prediction model for early nephropathy in elderly living with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Association of Relative Fat Mass and Conicity Index with the Risk of Hyperuricemia in Obese Women with PCOS: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Burden analysis of diabetic nephropathy caused by excessive intake of sugar-sweetened beverages in high and low SDI regions.Frontiers in public health · 2025Article
- Preparation and Efficacy Evaluation of Antihyperuricemic Peptides from Marine Sources.Nutrients · 2024Review
- In Vitro Spectroscopic Investigation of Losartan and Glipizide Competitive Binding to Glycated Albumin: A Comparative Study.International journal of molecular sciences · 2024Article
- A crucial role of adenosine deaminase in regulating gluconeogenesis in mice.The Journal of biological chemistry · 2024Article
- Association between uric acid and referable diabetic retinopathy in patients with type 2 diabetes.Scientific reports · 2024Article
- Serum uric acid is associated with chronic kidney disease in elderly Chinese patients with diabetes.Renal failure · 2023Article
- Establishment of a potent weighted risk model for determining the progression of diabetic kidney disease.Journal of translational medicine · 2023Article
- Renal Oxygen Demand and Nephron Function: Is Glucose a Friend or Foe?International journal of molecular sciences · 2023Review
- The association between dietary micronutrient patterns and odds of diabetic nephropathy: A case-control study.Food science & nutrition · 2023Article
- High-Fructose Diet-Induced Hyperuricemia Accompanying Metabolic Syndrome-Mechanisms and Dietary Therapy Proposals.International journal of environmental research and public health · 2023Review
- Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Clinical studies have reported associations between serum uric acid levels and the development of diabetic nephropathy, but the underlying mechanisms remain elusive. There is evidence from animal studies that blocking uric acid production protects the kidney from tubulointerstitial injury, which may suggest a causal role for uric acid in the development of diabetic tubular injury. In turn, when fructose, which is endogenously produced in diabetes via the polyol pathway, is metabolised, uric acid is generated from a side-chain reaction driven by ATP depletion and purine nucleotide turnover. For this reason, uric acid derived from endogenous fructose could cause tubulointerstitial injury in diabetes. Accordingly, our research group recently demonstrated that blocking fructose metabolism in a diabetic mouse model mitigated the development of tubulointerstitial injury by lowering tubular uric acid production. In this review we discuss the relationship between uric acid and fructose as a novel mechanism for the development of diabetic tubular injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.