Evidence map›Paper›PMID 26048960›Full record

ArticleNucleic acids research2015

R3D-2-MSA: the RNA 3D structure-to-multiple sequence alignment server.

Jamie J Cannone, Blake A Sweeney, Anton I Petrov, Robin R Gutell, Craig L Zirbel, Neocles Leontis

Abstract read
In one paragraph

Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jamie J CannoneInstitute for Cellular and Molecular Biology, and the Center for Computational Biology and Bioinformatics, The University of Texas at Austin, Austin, TX 78712, USA.
Blake A SweeneyDepartment of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.
Anton I PetrovEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.ORCID http://orcid.org/0000-0001-7279-2682
Robin R GutellInstitute for Cellular and Molecular Biology, and the Center for Computational Biology and Bioinformatics, The University of Texas at Austin, Austin, TX 78712, USA.
Craig L ZirbelDepartment of Mathematics and Statistics, Bowling Green State University, Bowling Green, OH 43403, USA.
Neocles LeontisDepartment of Chemistry, Bowling Green State University, Bowling Green, OH 43403, USA leontis@bgsu.edu.

Funding

RNA 3D Motif Search, Atlas, and Prediction from SequenceR01GM085328 · NIGMS · BOWLING GREEN STATE UNIVERSITY · PI ZIRBEL, CRAIG L · 2010 to 2023
$4.0M
The CRW Project: A Comparative Database of RNA MoleculesR01GM067317 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI GUTELL, ROBIN R · 2003 to 2012
$2.1M
Computational Foundations for Comparative RNA Sequence and StructureR01GM085337 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI ELBER, RON, GUTELL, ROBIN R · 2008 to 2011
$1.1M
SELECTION AND ANALYSIS OF STABLE RNA 3 WAY JUNCTIONSR15GM055898 · NIGMS · BOWLING GREEN STATE UNIVERSITY · PI LEONTIS, NEOCLES B · 1997 to 2010
$680k
NIGMS NIH HHS GM055898NIGMS NIH HHS GM067317NIGMS NIH HHS GM085328NIGMS NIH HHS GM085337NIGMS NIH HHS R01 GM067317NIGMS NIH HHS R01 GM085328NIGMS NIH HHS R01 GM085337NIGMS NIH HHS R15 GM055898
6 · The paper itself

Abstract

The RNA 3D Structure-to-Multiple Sequence Alignment Server (R3D-2-MSA) is a new web service that seamlessly links RNA three-dimensional (3D) structures to high-quality RNA multiple sequence alignments (MSAs) from diverse biological sources. In this first release, R3D-2-MSA provides manual and programmatic access to curated, representative ribosomal RNA sequence alignments from bacterial, archaeal, eukaryal and organellar ribosomes, using nucleotide numbers from representative atomic-resolution 3D structures. A web-based front end is available for manual entry and an Application Program Interface for programmatic access. Users can specify up to five ranges of nucleotides and 50 nucleotide positions per range. The R3D-2-MSA server maps these ranges to the appropriate columns of the corresponding MSA and returns the contents of the columns, either for display in a web browser or in JSON format for subsequent programmatic use. The browser output page provides a 3D interactive display of the query, a full list of sequence variants with taxonomic information and a statistical summary of distinct sequence variants found. The output can be filtered and sorted in the browser. Previous user queries can be viewed at any time by resubmitting the output URL, which encodes the search and re-generates the results. The service is freely available with no login requirement at http://rna.bgsu.edu/r3d-2-msa.

Indexed as

Sequence Analysis, RNASoftwareInternetNucleic Acid ConformationRNA, RibosomalSequence AlignmentRNA, Ribosomal

Identifiers

PMID26048960
PMCPMC4489222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.