ArticleApplied and environmental microbiology2015
Paenibacillus larvae-Directed Bacteriophage HB10c2 and Its Application in American Foulbrood-Affected Honey Bee Larvae.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed.
- Evaluating efficacy of oxytetracycline, lincomycin, and tylosin for treatment of clinical European foulbrood disease.Journal of insect science (Online) · 2026Article
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- Bacteriophage therapy against American foulbrood in honey bees: a PRISMA-guided systematic review.Frontiers in microbiology · 2026Review
- Bacteriophage resistance evolution in a honey bee pathogen.Microbiology (Reading, England) · 2025Article
- Genomic Analysis of 96Viruses · 2025Article
- Viral adaptations to alternative hosts in the honey bee pathogenbioRxiv : the preprint server for biology · 2024Article
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- Isolation, characterization, and comparative genomic analysis of vB_PlaM_Pd22F, a new bacteriophage of the family Myoviridae.Archives of virology · 2022Article
- Analysis of intact prophages in genomes ofFrontiers in microbiology · 2022Article
- Article
- Effects of Insecticides and Microbiological Contaminants onMolecules (Basel, Switzerland) · 2021Review
- Isolation and Characterization of Phages Active againstViruses · 2021Article
- Article
- Fructose and Trehalose Selectively Enhance In Vitro Sporulation ofMicroorganisms · 2021Article
- Antimicrobial Activity againstAntibiotics (Basel, Switzerland) · 2020Article
- Rapid identification and genotyping of the honeybee pathogenOpen veterinary journal · 2020Article
- Review
- Novel probiotic approach to counter Paenibacillus larvae infection in honey bees.The ISME journal · 2020Article
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Authors and funding
9 authors.
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Abstract
Paenibacillus larvae is the causative agent of American foulbrood (AFB), the most serious honey bee brood bacterial disease. We isolated and characterized P. larvae-directed bacteriophages and developed criteria for safe phage therapy. Whole-genome analysis of a highly lytic virus of the family Siphoviridae (HB10c2) provided a detailed safety profile and uncovered its lysogenic nature and a putative beta-lactamase-like protein. To rate its antagonistic activity against the pathogens targeted and to specify potentially harmful effects on the bee population and the environment, P. larvae genotypes ERIC I to IV, representatives of the bee gut microbiota, and a broad panel of members of the order Bacillales were analyzed for phage HB10c2-induced lysis. Breeding assays with infected bee larvae revealed that the in vitro phage activity observed was not predictive of the real-life scenario and therapeutic efficacy. On the basis of the disclosed P. larvae-bacteriophage coevolution, we discuss the future prospects of AFB phage therapy.
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