ArticleApplied and environmental microbiology2015
Identification of a Chemoreceptor for C2 and C3 Carboxylic Acids.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Chemoreceptor family in plant-associated bacteria responds preferentially to the plant signal molecule glycerol 3-phosphate.Genome biology · 2025Article
- Thermal shift assay to identify ligands for bacterial sensor proteins.FEMS microbiology reviews · 2025Review
- Bacterial biofilms as an essential component of rhizosphere plant-microbe interactions.Methods in microbiology · 2023Article
- A bacterial chemoreceptor that mediates chemotaxis to two different plant hormones.Environmental microbiology · 2022Article
- McpT, a Broad-Range Carboxylate Chemoreceptor in Sinorhizobium meliloti.Journal of bacteriology · 2021Article
- Chemotaxis of Beneficial Rhizobacteria to Root Exudates: The First Step towards Root-Microbe Rhizosphere Interactions.International journal of molecular sciences · 2021Review
- Chemotaxis of Pseudomonas putida F1 to Alcohols Is Mediated by the Carboxylic Acid Receptor McfP.Applied and environmental microbiology · 2019Article
- Hybrid Two-Component Sensors for Identification of Bacterial Chemoreceptor Function.Applied and environmental microbiology · 2019Article
- Chemotaxis Towards Aromatic Compounds: Insights fromInternational journal of molecular sciences · 2019Review
- Concentration Dependent Effect of Plant Root Exudates on the Chemosensory Systems ofFrontiers in microbiology · 2019Article
- Sinorhizobium meliloti Chemoreceptor McpV Senses Short-Chain Carboxylates via Direct Binding.Journal of bacteriology · 2018Article
- Functional Annotation of Bacterial Signal Transduction Systems: Progress and Challenges.International journal of molecular sciences · 2018Review
- Article
- In silico comparative analysis of GGDEF and EAL domain signaling proteins from the Azospirillum genomes.BMC microbiology · 2018Article
- The activity of the C4-dicarboxylic acid chemoreceptor of Pseudomonas aeruginosa is controlled by chemoattractants and antagonists.Scientific reports · 2018Article
- Sensory Repertoire of Bacterial Chemoreceptors.Microbiology and molecular biology reviews : MMBR · 2017Review
- Helicobacter pylori chemoreceptor TlpC mediates chemotaxis to lactate.Scientific reports · 2017Article
- The expression of many chemoreceptor genes depends on the cognate chemoeffector as well as on the growth medium and phase.Current genetics · 2017Article
- Metabolic Value Chemoattractants Are Preferentially Recognized at Broad Ligand Range Chemoreceptor ofFrontiers in microbiology · 2017Article
- Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae.Scientific reports · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemoreceptors are at the beginnings of chemosensory signaling cascades that mediate chemotaxis. Most bacterial chemoreceptors are functionally unannotated and are characterized by a diversity in the structure of their ligand binding domains (LBDs). The data available indicate that there are two major chemoreceptor families at the functional level, namely, those that respond to amino acids or to Krebs cycle intermediates. Since pseudomonads show chemotaxis to many different compounds and possess different types of chemoreceptors, they are model organisms to establish relationships between chemoreceptor structure and function. Here, we identify PP2861 (termed McpP) of Pseudomonas putida KT2440 as a chemoreceptor with a novel ligand profile. We show that the recombinant McpP LBD recognizes acetate, pyruvate, propionate, and l-lactate, with KD (equilibrium dissociation constant) values ranging from 34 to 107 μM. Deletion of the mcpP gene resulted in a dramatic reduction in chemotaxis toward these ligands, and complementation restored a native-like phenotype, indicating that McpP is the major chemoreceptor for these compounds. McpP has a CACHE-type LBD, and we present data indicating that CACHE-containing chemoreceptors of other species also mediate taxis to C2 and C3 carboxylic acids. In addition, the LBD of NbaY of Pseudomonas fluorescens, an McpP homologue mediating chemotaxis to 2-nitrobenzoate, bound neither nitrobenzoates nor the McpP ligands. This work provides further insight into receptor structure-function relationships and will be helpful to annotate chemoreceptors of other bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.