ArticleProceedings of the National Academy of Sciences of the United States of America2015
Transgenic songbirds with suppressed or enhanced activity of CREB transcription factor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Transcription factors Lef1 and Rest stimulate recovery from depressive states.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Lentivirus-Mediated Measurement of Transcription Factor Activity in the Brain.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Insights into Convergent Evolution From Studying Amino Acid Patterns in Independent Lineages of Birds.Genome biology and evolution · 2025Article
- Genome Editing in the Chicken: From PGC-Mediated Germline Transmission to Advanced Applications.International journal of molecular sciences · 2025Review
- A behavioral analysis system MCFBM enables objective inference of songbirds' attention during social interactions.Cell reports methods · 2024Article
- Goal-directed and flexible modulation of syllable sequence within birdsong.Nature communications · 2024Article
- Urbanization is associated with non-coding polymorphisms in candidate behavioural genes in the Eurasian coot.Ecology and evolution · 2023Article
- Review
- Reversible inhibition of the basal ganglia prolongs repetitive vocalization but only weakly affects sequencing at branch points in songbirds.Cerebral cortex communications · 2023Article
- Protocol for viral vector-mediated measurement of transcription factor activity of mouse brain.STAR protocols · 2022Article
- Generation and characterization of genome-modified chondrocyte-like cells from the zebra finch cell line immortalized by c-MYC expression.Frontiers in zoology · 2022Article
- PCR-based profiling of transcription factor activityiScience · 2022Article
- A Model of Discovery: The Role of Imaging Established and Emerging Non-mammalian Models in Neuroscience.Frontiers in molecular neuroscience · 2022Review
- Efficient gene transfer into zebra finch germline-competent stem cells using an adenoviral vector system.Scientific reports · 2021Article
- Article
- Highly Efficient Genome Modification of Cultured Primordial Germ Cells with Lentiviral Vectors to Generate Transgenic Songbirds.Stem cell reports · 2021Article
- Gene manipulation to test links between genome, brain and behavior in developing songbirds: a test case.The Journal of experimental biology · 2020Review
- Comparative Principles for Next-Generation Neuroscience.Frontiers in behavioral neuroscience · 2019Article
- Avian genomics lends insights into endocrine function in birds.General and comparative endocrinology · 2018Review
- Primordial germ cell-mediated transgenesis and genome editing in birds.Journal of animal science and biotechnology · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Songbirds postnatally develop their skill to utter and to perceive a vocal signal for communication. How genetic and environmental influences act in concert to regulate the development of such skill is not fully understood. Here, we report the phenotype of transgenic songbirds with altered intrinsic activity of cAMP response element-binding protein (CREB) transcription factor. By viral vector-mediated modification of genomic DNA, we established germ line-transmitted lines of zebra finches, which exhibited enhanced or suppressed activity of CREB. Although intrinsically acquired vocalizations or their hearing ability were not affected, the transgenic birds showed reduced vocal learning quality of their own songs and impaired audio-memory formation against conspecific songs. These results thus demonstrate that appropriate activity of CREB is necessary for the postnatal acquisition of learned behavior in songbirds, and the CREB transgenic birds offer a unique opportunity to separately manipulate both genetic and environmental factors that impinge on the postnatal song learning.
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