ArticlePlant physiology2015
Loss of FERULATE 5-HYDROXYLASE Leads to Mediator-Dependent Inhibition of Soluble Phenylpropanoid Biosynthesis in Arabidopsis.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Sinapoylglucose: malate sinapoyltransferase SNG1 negatively regulates drought resistance by crosstalk with abscisic acid signaling in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Reducing the Sinapine Levels of Camelina sativa Seeds Through Targeted Genome Editing of REF1.Plant biotechnology journal · 2026Article
- Reveal genomic insights into cotton domestication and improvement using gene level functional haplotype-based GWAS.Nature communications · 2025Article
- Photoreceptor-induced sinapate synthesis contributes to photoprotection in Arabidopsis.Plant physiology · 2024Article
- The heat shock factor 20-HSF4-cellulose synthase A2 module regulates heat stress tolerance in maize.The Plant cell · 2024Article
- Transcriptomic and metabolomic analyses reveal the mechanism of color difference between two kinds ofFrontiers in plant science · 2024Article
- Transcript and metabolite network perturbations in lignin biosynthetic mutants of Arabidopsis.Plant physiology · 2022Article
- An insight into microRNA biogenesis and its regulatory role in plant secondary metabolism.Plant cell reports · 2022Review
- Combined transcriptome and metabolome analysis of Nerium indicum L. elaborates the key pathways that are activated in response to witches' broom disease.BMC plant biology · 2022Article
- The Mediator Complex: A Central Coordinator of Plant Adaptive Responses to Environmental Stresses.International journal of molecular sciences · 2022Review
- The Transcriptome Profiling of Flavonoids and Bibenzyls Reveals Medicinal Importance of Rare OrchidFrontiers in plant science · 2022Article
- Metabolic source isotopic pair labeling and genome-wide association are complementary tools for the identification of metabolite-gene associations in plants.The Plant cell · 2021Article
- Transcriptomic Analyses Shed Light on Critical Genes Associated with Bibenzyl Biosynthesis inPlants (Basel, Switzerland) · 2021Article
- Multiscale characterization and micromechanical modeling of crop stem materials.Biomechanics and modeling in mechanobiology · 2021Article
- Metabolite profiling of violet, white and pink flowers revealing flavonoids composition patterns inJournal of biosciences · 2021Article
- Transcriptomic analysis of cytochrome P450 genes and pathways involved in chromium toxicity in Oryza sativa.Ecotoxicology (London, England) · 2020Article
- A noninvasive, machine learning-based method for monitoring anthocyanin accumulation in plants using digital color imaging.Applications in plant sciences · 2019Article
- Transcriptome divergence during leaf development in two contrasting switchgrass (Panicum virgatum L.) cultivars.PloS one · 2019Article
- The cell biology of secondary cell wall biosynthesis.Annals of botany · 2018Review
- Stacking of a low-lignin trait with an increased guaiacyl and 5-hydroxyguaiacyl unit trait leads to additive and synergistic effects on saccharification efficiency inBiotechnology for biofuels · 2018Article
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4 authors.
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Abstract
Phenylpropanoids are phenylalanine-derived specialized metabolites and include important structural components of plant cell walls, such as lignin and hydroxycinnamic acids, as well as ultraviolet and visible light-absorbing pigments, such as hydroxycinnamate esters (HCEs) and anthocyanins. Previous work has revealed a remarkable degree of plasticity in HCE biosynthesis, such that most Arabidopsis (Arabidopsis thaliana) mutants with blockages in the pathway simply redirect carbon flux to atypical HCEs. In contrast, the ferulic acid hydroxylase1 (fah1) mutant accumulates greatly reduced levels of HCEs, suggesting that phenylpropanoid biosynthesis may be repressed in response to the loss of FERULATE 5-HYDROXYLASE (F5H) activity. Here, we show that in fah1 mutant plants, the activity of HCE biosynthetic enzymes is not limiting for HCE accumulation, nor is phenylpropanoid flux diverted to the synthesis of cell wall components or flavonol glycosides. We further show that anthocyanin accumulation is also repressed in fah1 mutants and that this repression is specific to tissues in which F5H is normally expressed. Finally, we show that repression of both HCE and anthocyanin biosynthesis in fah1 mutants is dependent on the MED5a/5b subunits of the transcriptional coregulatory complex Mediator, which are similarly required for the repression of lignin biosynthesis and the stunted growth of the phenylpropanoid pathway mutant reduced epidermal fluorescence8. Taken together, these observations show that the synthesis of HCEs and anthocyanins is actively repressed in a MEDIATOR-dependent manner in Arabidopsis fah1 mutants and support an emerging model in which MED5a/5b act as central players in the homeostatic repression of phenylpropanoid metabolism.
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