ArticleThe Plant cell2015
Involvement of Arabidopsis Hexokinase1 in Cell Death Mediated by Myo-Inositol Accumulation.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Genome-Wide Identification and Expression Analysis of Hexokinase Gene Family Under Abiotic Stress in Tomato.Plants (Basel, Switzerland) · 2025Article
- The host and pathogen myo-inositol-1-phosphate synthases are required for Rhizoctonia solani AG1-IA infection in tomato.Molecular plant pathology · 2024Article
- Plants distinguish different photoperiods to independently control seasonal flowering and growth.Science (New York, N.Y.) · 2024Article
- Sugar coordinates plant defense signaling.Science advances · 2024Article
- HEXOKINASE1 and glucose-6-phosphate fuel plant growth and development.Development (Cambridge, England) · 2023Article
- Genetic mapping and prediction for novel lesion mimic in maize demonstrates quantitative effects from genetic background, environment and epistasis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Genome-Wide Survey and Expression Analyses of Hexokinase Family in Poplar (Plants (Basel, Switzerland) · 2022Article
- Neofunctionalization of Glycolytic Enzymes: An Evolutionary Route to Plant Parasitism in the OomyceteMicroorganisms · 2022Article
- TheFrontiers in plant science · 2022Article
- Dynamic Nutrient Signaling Networks in Plants.Annual review of cell and developmental biology · 2021Review
- ARGONAUTE 2 increases rice susceptibility to rice black-streaked dwarf virus infection by epigenetically regulating HEXOKINASE 1 expression.Molecular plant pathology · 2021Article
- MOS1 Negatively Regulates Sugar Responses and Anthocyanin Biosynthesis in Arabidopsis.International journal of molecular sciences · 2020Article
- Involvement of Arabidopsis BIG protein in cell death mediated by Myo-inositol homeostasis.Scientific reports · 2020Article
- Effects of Salicylic Acid on the Metabolism of Mitochondrial Reactive Oxygen Species in Plants.Biomolecules · 2020Review
- Article
- MdUGT88F1-Mediated Phloridzin Biosynthesis Regulates Apple Development andPlant physiology · 2019Article
- WRKY18 and WRKY53 Coordinate with HISTONE ACETYLTRANSFERASE1 to Regulate Rapid Responses to Sugar.Plant physiology · 2019Article
- Article
- Salicylic acid-induced ROS production by mitochondrial electron transport chain depends on the activity of mitochondrial hexokinases in tomato (Solanum lycopersicum L.).Journal of plant research · 2019Article
- The Sugar-Signaling Hub: Overview of Regulators and Interaction with the Hormonal and Metabolic Network.International journal of molecular sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Programmed cell death (PCD) is essential for several aspects of plant life, including development and stress responses. We recently identified the mips1 mutant of Arabidopsis thaliana, which is deficient for the enzyme catalyzing the limiting step of myo-inositol (MI) synthesis. One of the most striking features of mips1 is the light-dependent formation of lesions on leaves due to salicylic acid (SA)-dependent PCD. Here, we identified a suppressor of PCD by screening for mutations that abolish the mips1 cell death phenotype. Our screen identified the hxk1 mutant, mutated in the gene encoding the hexokinase1 (HXK1) enzyme that catalyzes sugar phosphorylation and acts as a genuine glucose sensor. We show that HXK1 is required for lesion formation in mips1 due to alterations in MI content, via SA-dependant signaling. Using two catalytically inactive HXK1 mutants, we also show that hexokinase catalytic activity is necessary for the establishment of lesions in mips1. Gas chromatography-mass spectrometry analyses revealed a restoration of the MI content in mips1 hxk1 that it is due to the activity of the MIPS2 isoform, while MIPS3 is not involved. Our work defines a pathway of HXK1-mediated cell death in plants and demonstrates that two MIPS enzymes act cooperatively under a particular metabolic status, highlighting a novel checkpoint of MI homeostasis in plants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.