ArticleBioMedicine2015
P-coumaric acid regulates exon 12 splicing of the ATP7B gene by modulating hnRNP A1 protein expressions.
Article in BioMedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Chinese Herbal Medicine for Wilson's Disease: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2019Pooled it
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- Your height affects your health: genetic determinants and health-related outcomes in Taiwan.BMC medicine · 2022Article
- Effect of Chinese Herbal Medicine Therapy on Risks of Overall, Diabetes-Related, and Cardiovascular Diseases-Related Mortalities in Taiwanese Patients With Hereditary Hemolytic Anemias.Frontiers in pharmacology · 2022Article
- hnRNP A1 in RNA metabolism regulation and as a potential therapeutic target.Frontiers in pharmacology · 2022Review
- Heterogeneous nuclear ribonucleoprotein hnRNPA2/B1 regulates the abundance of the copper-transporter ATP7A in an isoform-dependent manner.Frontiers in molecular biosciences · 2022Article
- Chinese Herbal Medicine Therapy Reduces the Risks of Overall and Anemia-Related Mortalities in Patients With Aplastic Anemia: A Nationwide Retrospective Study in Taiwan.Frontiers in pharmacology · 2021Article
- Impacts of RETN genetic polymorphism on breast cancer development.Journal of Cancer · 2020Article
- Variations in theInternational journal of medical sciences · 2018Article
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- Association of Resistin Gene Polymorphisms with Oral Squamous Cell Carcinoma Progression and Development.BioMed research international · 2018Article
- FSCN1 gene polymorphisms: biomarkers for the development and progression of breast cancer.Scientific reports · 2017Article
- Head and neck cancer associated with increased rate of pulmonary tuberculosis in a population-based cohort study.Medicine · 2017Article
- Use of thiazolidinediones and risk of hip fracture in old people in a case-control study in Taiwan.Medicine · 2017Observational
- Synergistic inhibition of leukemia WEHI-3 cell growth by arsenic trioxide andExperimental and therapeutic medicine · 2017Article
- Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo.Scientific reports · 2017Article
- Bufalin Induces Apoptosis of Human Osteosarcoma U-2 OS Cells through Endoplasmic Reticulum Stress, Caspase- and Mitochondria-Dependent Signaling Pathways.Molecules (Basel, Switzerland) · 2017Article
- Metformin Use Correlates with Reduced Risk of Gallstones in Diabetic Patients: A 12-Year Follow-up Study.Frontiers in pharmacology · 2017Article
- Impacts of CCL4 gene polymorphisms on hepatocellular carcinoma susceptibility and development.International journal of medical sciences · 2017Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWilson's disease (WD) is a genetic disorder involving the metabolism of copper. WD patients exhibit a wide range of disease phenotypes, including Kayser-Fleischer rings in the cornea, predominant progressive hepatic disease, neurological diseases, and/or psychiatric illnesses, among others. Patients with exon12 mutations of the ATP7B gene have progressive hepatic disease. An ATP7B gene that lacks exon12 retains 80% of its copper transport activities, suggesting that alternative splicing of ATP7B gene may provide alternative therapeutic ways for patients with inherited sequence variants and mutations of this gene. PURPOSE: We aimed to search for possible Chinese herbs and related compounds for modulating ATP7B premRNA splicing.
methodsWe used an ATP7B exon11-12-13 mini-gene vector as a model and screened 18 Chinese herbal extracts and four compounds from Schizonepeta to determine their effects on ATP7B pre-mRNA splicing in vitro.
resultsWe found that Schizonepeta demonstrated the greatest potential for alternative splicing activity. Specifically, we found that p-coumaric acid from this herb enhanced ATP7B exon12 exclusion through the down-regulation of heterogeneous ribonucleoprotein (hnRNP) A1 protein expressions.
conclusionThese results suggest that there are herbs or herb-related compounds that could modify the alternative splicing of the ATP7B gene via a mechanism that regulates pre-mRNA splicing.
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