Trial reportDrug and alcohol dependence2015
A single dose of kudzu extract reduces alcohol consumption in a binge drinking paradigm.
Trial report in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Effects of kudzu extract on alcohol consumption among men and women seeking treatment for alcohol use disorder.Drug and alcohol dependence reports · 2026Article
- Development of reference materials for dietary supplements-analytical challenges, use, limitations, and future needs.Analytical and bioanalytical chemistry · 2025Review
- Pharmaceutical Humanities and Narrative Pharmacy: An Emerging New Concept in Pharmacy.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Emerging pharmacological targets for alcohol use disorder.Alcohol (Fayetteville, N.Y.) · 2024Review
- Puerarin: a hepatoprotective drug from bench to bedside.Chinese medicine · 2024Review
- Suppression of P2X4 and P2X7 by Lactobacillus rhamnosus vitaP1: effects on hangover symptoms.AMB Express · 2024Article
- Study on structural characteristics, physicochemical properties, and in vitro digestibility of Kudzu-resistant starch prepared by different methods.Food science & nutrition · 2023Article
- Development of Kudzu (Pueraria Montana var. lobata) Reference Materials for the Determination of Isoflavones and Toxic Elements.Journal of AOAC International · 2022Article
- Differential Influence ofPharmaceuticals (Basel, Switzerland) · 2021Article
- Article
- The Efficacy and Safety of Multiple Dose Regimens of Kudzu (Frontiers in pharmacology · 2021Article
- Plants with Anti-Addictive Potential.Advances in experimental medicine and biology · 2021Article
- Applications ofChinese herbal medicines · 2019Article
- Soy Isoflavone Extract Does Not Increase the Intoxicating Effects of Acute Alcohol Ingestion in Human Volunteers.Frontiers in pharmacology · 2019Article
- Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook.Frontiers in pharmacology · 2019Review
- Potent suppression of HIV-1 cell attachment by Kudzu root extract.Retrovirology · 2018Article
- Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder.Molecules (Basel, Switzerland) · 2016Review
- Characteristics of Dispensary Patients that Limit Alcohol after Initiating Cannabis.Journal of psychoactive drugsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOverconsumption of alcohol has significant negative effects on an individual's health and contributes to an enormous economic impact on society as a whole. Pharmacotherapies to curb excessive drinking are important for treating alcohol use disorders.
methodsTwenty (20) men participated in a placebo-controlled, double-blind, between subjects design experiment (n=10/group) that tested the effects of kudzu extract (Alkontrol-Herbal™) for its ability to alter alcohol consumption in a natural settings laboratory. A single dose of kudzu extract (2g total with an active isoflavone content of 520mg) or placebo was administered 2.5h before the onset of a 90min afternoon drinking session during which participants had the opportunity to drink up to 6 beers ad libitum; water and juice were always available as alternative beverages.
resultsDuring the baseline session, the placebo-randomized group consumed 2.7±0.78 beers before treatment and increased consumption to 3.4±1.1 beers after treatment. The kudzu group significantly reduced consumption from 3.0±1.7 at baseline to 1.9±1.3 beers after treatment. The placebo-treated group opened 33 beers during baseline conditions and 38 following treatment whereas the kudzu-treated group opened 32 beers during baseline conditions and only 21 following treatment. Additionally, kudzu-treated participants drank slower.
conclusionThis is the first demonstration that a single dose of kudzu extract quickly reduces alcohol consumption in a binge drinking paradigm. These data add to the mounting clinical evidence that kudzu extract may be a safe and effective adjunctive pharmacotherapy for alcohol abuse and dependence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.