ArticleBMC genomics2015
Recent genomic heritage in Scotland.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank.Translational psychiatry · 2018Pooled it
- Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder.PloS one · 2018Pooled it
- Genome-wide analysis of 439 mass spectrometry-based proteomic profiles in a population of 15,035 Scottish individuals.Nature communications · 2026Article
- Blood-based DNA methylation captures variance in adult height.Genome biology · 2026Article
- Data Resource Profile: Whole-Blood DNA Methylation Resource in Generation Scotland (MeGS).International journal of epidemiology · 2025Article
- An analysis of the accuracy of retrospective birth location recall using sibling data.Nature communications · 2024Article
- Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health.Nature communications · 2022Article
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- Article
- Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome.EBioMedicine · 2021Article
- Genome-wide methylation data improves dissection of the effect of smoking on body mass index.PLoS genetics · 2021Article
- Genetic mechanisms of critical illness in COVID-19.Nature · 2021Article
- Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles.Genome medicine · 2021Article
- SNP and Haplotype Regional Heritability Mapping (SNHap-RHM): Joint Mapping of Common and Rare Variation Affecting Complex Traits.Frontiers in genetics · 2021Review
- DNA methylation outlier burden, health, and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936.Clinical epigenetics · 2020Article
- The genetic landscape of Scotland and the Isles.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cardiac Troponin T and Troponin I in the General Population.Circulation · 2019Article
- Parent of origin genetic effects on methylation in humans are common and influence complex trait variation.Nature communications · 2019Article
- A validation of the diathesis-stress model for depression in Generation Scotland.Translational psychiatry · 2019Article
- Genomic analysis of family data reveals additional genetic effects on intelligence and personality.Molecular psychiatry · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundThe Generation Scotland Scottish Family Health Study (GS:SFHS) includes 23,960 participants from across Scotland with records for many health-related traits and environmental covariates. Genotypes at ~700 K SNPs are currently available for 10,000 participants. The cohort was designed as a resource for genetic and health related research and the study of complex traits. In this study we developed a suite of analyses to disentangle the genomic differentiation within GS:SFHS individuals to describe and optimise the sample and methods for future analyses.
resultsWe combined the genotypic information of GS:SFHS with 1092 individuals from the 1000 Genomes project and estimated their genomic relationships. Then, we performed Principal Component Analyses of the resulting relationships to investigate the genomic origin of different groups. We characterised two groups of individuals: those with a few sparse rare markers in the genome, and those with several large rare haplotypes which might represent relatively recent exogenous ancestors. We identified some individuals with likely Italian ancestry and a group with some potential African/Asian ancestry. An analysis of homozygosity in the GS:SFHS sample revealed a very similar pattern to other European populations. We also identified an individual carrying a chromosome 1 uniparental disomy. We found evidence of local geographic stratification within the population having impact on the genomic structure.
conclusionsThese findings illuminate the history of the Scottish population and have implications for further analyses such as the study of the contributions of common and rare variants to trait heritabilities and the evaluation of genomic and phenotypic prediction of disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.