Evidence map›Paper›PMID 26048305›Full record

ReviewPhysiology & behavior2015

Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism.

Mary V Burke, Dana M Small

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physiology & behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03972176 (Determination of Perinatal Exposure to Non-caloric Sweeteners. Implications for the Development of Preferences for Sweet Taste, and Weight Gain During the First Year of Life), which is not on this map. Cited by 52 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03972176 unknown statusnot on this mapstarted 2019, after this paper: background citation

Determination of Perinatal Exposure to Non-caloric Sweeteners. Implications for the Development of Preferences for Sweet Taste, and Weight Gain During the First Year of Life

Typeobservational_patient_registrySponsorUniversity of ChileRan2019 to 2021Enrolled315ConditionsExposures Associated With Pregnancy, Delivery and Lactation
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  16. Article
  17. Dietary Polysaccharide-Rich Extract from Noni (Animals : an open access journal from MDPI · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mary V BurkeYale Interdepartmental Neuroscience Program, Yale Medical School, New Haven, CT, USA; John B. Pierce Laboratory, 290 Congress Avenue, New Haven, CT, USA. Electronic address: mary.burke@yale.edu.
Dana M SmallYale Interdepartmental Neuroscience Program, Yale Medical School, New Haven, CT, USA; John B. Pierce Laboratory, 290 Congress Avenue, New Haven, CT, USA; Department of Psychiatry, Yale Medical School, New Haven, CT, USA; Department of Psychology, Yale University, New Haven, CT, USA; Center for Excellence, University of Cologne, Cologne, Germany. Electronic address: dana.small@yale.edu.

Funding

Interdepartmental Neuroscience Program (INP)T32NS041228 · NINDS · YALE UNIVERSITY · PI Charles A Greer, Marina R Picciotto · 2001 to 2026
$12.0M
Cognitive and affective influences on taste processingR01DC006706 · NIDCD · YALE UNIVERSITY · PI SMALL, DANA M · 2006 to 2018
$5.3M
(PQA3) The gut-brain axis: a novel target for treating behavioral alterations inR01CA180030 · NCI · JOHN B. PIERCE LABORATORY, INC. · PI DE ARAUJO, IVAN E, SMALL, DANA M · 2013 to 2016
$2.6M
NCI NIH HHS R01 CA180030NIDCD NIH HHS R01 DC006706NIDDK NIH HHS R01 DK095579NINDS NIH HHS T32 NS041228NINDS NIH HHS T32 NS41228
6 · The paper itself

Abstract

Evidence linking sugar-sweetened beverage (SSB) consumption to weight gain and other negative health outcomes has prompted many individuals to resort to artificial, non-nutritive sweetener (NNS) substitutes as a means of reducing SSB intake. However, there is a great deal of controversy regarding the biological consequences of NNS use, with accumulating evidence suggesting that NNS consumption may influence feeding and metabolism via a variety of peripheral and central mechanisms. Here we argue that NNSs are not physiologically inert compounds and consider the potential biological mechanisms by which NNS consumption may impact energy balance and metabolic function, including actions on oral and extra-oral sweet taste receptors, and effects on metabolic hormone secretion, cognitive processes (e.g. reward learning, memory, and taste perception), and gut microbiota.

Indexed as

Administration, OralAnimalsBody WeightDrinking BehaviorEnergy MetabolismGastrointestinal MicrobiomeHumansNon-Nutritive SweetenersRewardNon-Nutritive SweetenersBody weightBrainEnergy balanceFeedingGutMetabolismNon-nutritive sweetenersObesitySweetening agentsTaste perception

Identifiers

PMID26048305
PMCPMC4661139

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.