Evidence map›Paper›PMID 26048182›Full record

ArticleBMC microbiology2015

Polyelectrolyte-mediated increase of biofilm mass formation.

Robert Bucki, Katarzyna Niemirowicz, Urszula Wnorowska, Marzena Wątek, Fitzroy J Byfield, Katrina Cruz, Marta Wróblewska, Paul A Janmey

Open access · goldAbstract read
In one paragraph

Article in BMC microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Modulation of Biofilm Mechanics by DNA Structure and Cell Type.ACS biomaterials science & engineering · 2022
    Article
  3. Article
  4. Article
  5. Optimized Method forFrontiers in microbiology · 2021
    Article
  6. Article
  7. Susceptibility of microbial cells to the modified PIPJournal of nanobiotechnology · 2019
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Robert BuckiDepartment of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, ul. Mickiewicza 2C, Bialystok, 15-222, Poland. buckirobert@gmail.com.
Katarzyna NiemirowiczDepartment of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, ul. Mickiewicza 2C, Bialystok, 15-222, Poland. katia146@wp.pl.
Urszula WnorowskaDepartment of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, ul. Mickiewicza 2C, Bialystok, 15-222, Poland. u.wnorowska@gmail.com.
Marzena WątekDepartment of Hematology, Holy Cross Oncology Center of Kielce, Kielce, Poland. marzena.watek@wp.pl.
Fitzroy J ByfieldDepartment of Physiology and the Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA. fbyfield@mail.med.upenn.edu.
Katrina CruzDepartment of Physiology and the Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA. katcruz@mail.med.upenn.edu.
Marta WróblewskaDepartment of Dental Microbiology, Medical University of Warsaw, Warsaw, Poland. martamwroblewska@gmail.com.
Paul A JanmeyDepartment of Physiology and the Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA. janmey@mail.med.upenn.edu.
University of Pennsylvania · USMedical University of Białystok · PLHoly Cross University · PLJan Kochanowski University · PLMedical University of Warsaw · PL

Funding

Structural basis of the specific protein-protein interactions underlying IF assemP01GM096971 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOLDMAN, ROBERT D · 2011 to 2021
$16.8M
NIGMS NIH HHS P01 GM096971
6 · The paper itself

Abstract

backgroundBiofilm formation is associated with various aspects of bacterial and fungal infection. This study was designed to assess the impact of diverse natural polyelectrolytes, such as DNA, F-actin, neurofilaments (NFs), vimentin and purified Pf1 bacteriophage on biofilm formation and swarming motility of select pathogens including Pseudomonas aeruginosa associated with lung infections in CF patients.

resultsThe bacteriophage Pf1 (1 mg/ml) significantly increased biofilm mass produced by Pseudomonas aeruginosa P14, Escherichia coli RS218 and Bacillus subtilis ATCC6051. DNA, F-actin, NFs and Pf1 also increased biofilm mass of the fungal C. albicans 1409 strain. Addition of F-actin, DNA or Pf1 bacteriophage to 0.5% agar plates increased swarming motility of Pseudomonas aeruginosa Xen5.

conclusionsThe presence of polyelectrolytes at infection sites is likely to promote biofilm growth and bacterial swarming.

Indexed as

ActinsBacterial Physiological PhenomenaBacteriophage Pf1BiofilmsCell LineDNAElectrolytesHumansIntermediate FilamentsPolymersVimentinActinsDNAElectrolytesPolymersVimentin

Identifiers

PMID26048182
PMCPMC4458031
OpenAlexW2125862448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.