Trial reportSocial cognitive and affective neuroscience2015
Mindfulness meditation training alters stress-related amygdala resting state functional connectivity: a randomized controlled trial.
Trial report in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The Neuroscience of Religious and Spiritual Practices: A Systematic Review of Neurotheological Evidence.Brain and behavior · 2026Pooled it
- Interventions Based on Biofeedback Systems to Improve Workers' Psychological Well-Being, Mental Health, and Safety: Systematic Literature Review.Journal of medical Internet research · 2025Pooled it
- Meta-analytic evidence that mindfulness training alters resting state default mode network connectivity.Scientific reports · 2022Pooled it
- Mindfulness in the focus of the neurosciences - The contribution of neuroimaging to the understanding of mindfulness.Frontiers in behavioral neuroscience · 2022Pooled it
- Mindfulness, Compassion, and Self-Compassion Among Health Care Professionals: What's New? A Systematic Review.Frontiers in psychology · 2020Pooled it
- The health impact of residential retreats: a systematic review.BMC complementary and alternative medicine · 2018Pooled it
- Metabolomic profiles impacted by brief mindfulness intervention with contributions to improved health.Scientific reports · 2025Trial
- Autonomic modulation with mindfulness-based stress reduction in chronic kidney disease: a randomized controlled trial.The Journal of physiology · 2025Trial
- Mindful attention promotes control of brain network dynamics for self-regulation and discontinues the past from the present.Proceedings of the National Academy of Sciences of the United States of America · 2023Trial
- Mindfulness meditation increases default mode, salience, and central executive network connectivity.Scientific reports · 2022Trial
- Effect of Mindfulness-Based Stress Reduction on dehydroepiandrosterone-sulfate in adults with self-reported stress. A randomized trial.Clinical and translational science · 2021Trial
- Trial
- Mindfulness training preserves sustained attention and resting state anticorrelation between default-mode network and dorsolateral prefrontal cortex: A randomized controlled trial.Human brain mapping · 2020Trial
- Mindfulness-Based Meditation Versus Progressive Relaxation Meditation: Impact on Chronic Pain in Older Female Patients With Diabetic Neuropathy.Journal of evidence-based integrative medicineTrial
- Association of psychosocial stress with altered functional connectivity of large-scale brain networks in aging adults.Cognitive, affective & behavioral neuroscience · 2026Article
- Case Report: A Multimodal Treatment Approach Combining Multi-Target rTMS with a Modified, Largely Self-Administered, Clinician-Supervised Exposure and Response Prevention Protocol Using a Verbal Termination Cue in Two Patients with Severe Obsessive-Compulsive Disorder.Journal of clinical medicine · 2026Article
- Enhancing resilience, flexibility, and well-being through cognitive-emotional training: behavioral and neural evidence.Scientific reports · 2026Article
- Brain resting state functional connectivity changes with aerobic exercise, and mindfulness: A narrative review.Sports medicine and health science · 2026Review
- Enhancing Physiological Complexity Through Mindfulness: A Wearable-Based Intervention for First Responders and Their Partners.Healthcare (Basel, Switzerland) · 2026Article
- Virtual Reality-Based Pain Modulation in Subacute Musculoskeletal Injury: Functional Near-Infrared Spectroscopy Study of Neural and Behavioral Correlates.JMIR serious games · 2026Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Recent studies indicate that mindfulness meditation training interventions reduce stress and improve stress-related health outcomes, but the neural pathways for these effects are unknown. The present research evaluates whether mindfulness meditation training alters resting state functional connectivity (rsFC) of the amygdala, a region known to coordinate stress processing and physiological stress responses. We show in an initial discovery study that higher perceived stress over the past month is associated with greater bilateral amygdala-subgenual anterior cingulate cortex (sgACC) rsFC in a sample of community adults (n = 130). A follow-up, single-blind randomized controlled trial shows that a 3-day intensive mindfulness meditation training intervention (relative to a well-matched 3-day relaxation training intervention without a mindfulness component) reduced right amygdala-sgACC rsFC in a sample of stressed unemployed community adults (n = 35). Although stress may increase amygdala-sgACC rsFC, brief training in mindfulness meditation could reverse these effects. This work provides an initial indication that mindfulness meditation training promotes functional neuroplastic changes, suggesting an amygdala-sgACC pathway for stress reduction effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.