ArticleBMC microbiology2015
Violacein induces cell death by triggering mitochondrial membrane hyperpolarization in vitro.
Article in BMC microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Hierarchically Engineered Multi-Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- The Role of Biofilm-Derived Compounds in Microbial and Protozoan Interactions.Microorganisms · 2025Review
- Violacein-Loaded Outer Membrane Vesicles fromACS biomaterials science & engineering · 2025Article
- Quorum Sensing inMicroorganisms · 2025Article
- Extracellular vesicles of Janthinobacterium lividum as violacein carriers in melanoma cell treatment.Applied microbiology and biotechnology · 2024Article
- Antitumor activity of natural pigment violacein against osteosarcoma and rhabdomyosarcoma cell lines.Journal of cancer research and clinical oncology · 2023Article
- Cytotoxicity, Mitochondrial Functionality, and Redox Status of Human Conjunctival Cells after Short and Chronic Exposure to Preservative-Free Bimatoprost 0.03% and 0.01%: An In Vitro Comparative Study.International journal of molecular sciences · 2022Article
- Antimicrobial Activity of the Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG) against Clinical Isolates of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Evaluation of the anti-proliferative activity of violacein, a natural pigment of bacterial origin, in urinary bladder cancer cell lines.Oncology letters · 2022Article
- Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis.Scientific reports · 2022Article
- Article
- Potential Antimicrobial Properties of Coffee Beans and Coffee By-Products Against Drug-ResistantFrontiers in nutrition · 2022Article
- Characterization of Anti-Cancer Activities of Violacein: Actions on Tumor Cells and the Tumor Microenvironment.Frontiers in oncology · 2022Article
- Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production.Journal of microbiology and biotechnology · 2021Review
- Multi-target drug with potential applications: violacein in the spotlight.World journal of microbiology & biotechnology · 2021Review
- Biotechnological Activities and Applications of Bacterial Pigments Violacein and Prodigiosin.Journal of biological engineering · 2021Review
- Palladium Nanoparticle-Induced Oxidative Stress, Endoplasmic Reticulum Stress, Apoptosis, and Immunomodulation Enhance the Biogenesis and Release of Exosome in Human Leukemia Monocytic Cells (THP-1).International journal of nanomedicine · 2021Article
- A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids.PLoS pathogens · 2020Article
- Production and antiproliferative effect of violacein, a purple pigment produced by an Antarctic bacterial isolate.World journal of microbiology & biotechnology · 2020Article
- Melatonin Enhances Palladium-Nanoparticle-Induced Cytotoxicity and Apoptosis in Human Lung Epithelial Adenocarcinoma Cells A549 and H1229.Antioxidants (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundViolacein is a purple pigment from Chromobacterium violaceum that possesses diverse biological and pharmacological properties. Among these, pro-oxidant and antioxidant activities have been suggested. However, the cytotoxic mechanisms induced by violacein are poorly understood and the improvement in knowledge regarding these cell death mechanisms will be useful to develop new therapeutic approaches. Considering this, in our work, we investigated the pro-oxidant effects of violacein in non-tumor (CHO-K1 and MRC-5) and tumor (HeLa) cell lines, searching for a better understanding of reactive oxygen species (ROS) production and cell death induction.
resultsCytotoxicity induced by violacein was observed in the three cell lines; however, MRC-5 and HeLa cells were shown to be more sensitive to violacein treatment. Although punctual alterations in the antioxidant apparatus and increase in oxidative stress biomarkers was observed in some violacein concentrations, no association was found between increased oxidative stress and induction of cell death. However, the increase of mitochondrial membrane potential was observed.
conclusionsIn fact, the increase of mitochondrial membrane potential in MRC-5 and HeLa cells suggests that mitochondrial membrane hyperpolarization might be the main cause of cell death triggered by violacein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.