Evidence map›Paper›PMID 26047963›Full record

Trial reportPsychopharmacology2015

The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial.

Daniel J Lamport, Deepa Pal, Christina Moutsiana, David T Field, Claire M Williams, Jeremy P E Spencer, Laurie T Butler

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06812689 (The Acute Effects of Cocoa Flavanols Intake on Overt and Covert Attention), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06812689 nacompletednot on this mapstarted 2022, after this paper: background citation

The Acute Effects of Cocoa Flavanols Intake on Overt and Covert Attention: a Randomized, Double-blind Crossover Trial

TypeinterventionalSponsorKonya Necmettin Erbakan ÜniversitesiRan2022 to 2023Enrolled48ConditionsHealthy Young AdultsArmsFlavanol, Placebo, Sugar water
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniel J LamportSchool of Psychology and Clinical Language Sciences, University of Reading, Reading, RG6 6AP, UK, d.j.lamport@reading.ac.uk.
Deepa Pal
Christina Moutsiana
David T Field
Claire M Williams
Jeremy P E Spencer
Laurie T Butler
University of Reading · GB

Funding

Biotechnology and Biological Sciences Research Council BB/F008953/1Biotechnology and Biological Sciences Research Council BB/G005702/1
6 · The paper itself

Abstract

rationaleThere has recently been increasing interest in the potential of flavanols, plant-derived compounds found in foods such as fruit and vegetables, to ameliorate age-related cognitive decline. Research suggests that cocoa flavanols improve memory and learning, possibly as a result of their anti-inflammatory and neuroprotective effects. These effects may be mediated by increased cerebral blood flow (CBF), thus, stimulating neuronal function.

objectivesThe present study employed arterial spin labelling functional magnetic resonance imaging to explore the effect of a single acute dose of cocoa flavanols on regional CBF.

methodsCBF was measured pre- and post-consumption of low (23 mg) or high (494 mg) 330 ml equicaloric flavanol drinks matched for caffeine, theobromine, taste and appearance according to a randomized counterbalanced crossover double-blind design in eight males and ten females, aged 50-65 years. Changes in perfusion from pre- to post-consumption were calculated as a function of each drink.

resultsSignificant increases in regional perfusion across the brain were observed following consumption of the high flavanol drink relative to the low flavanol drink, particularly in the anterior cingulate cortex and the central opercular cortex of the parietal lobe.

conclusionsConsumption of cocoa flavanol improves regional cerebral perfusion in older adults. This provides evidence for a possible acute mechanism by which cocoa flavanols are associated with benefits for cognitive performance.

Indexed as

AdultAgedBeveragesCacaoCerebral CortexCerebrovascular CirculationCross-Over StudiesDouble-Blind MethodFemaleFlavonolsHealthy VolunteersHumansMagnetic Resonance ImagingMaleMiddle AgedParietal LobeFlavonolsPolyphenolsTheobromine

Identifiers

PMID26047963
PMCPMC4534492
OpenAlexW357675528

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.