ArticleEndocrine connections2015
The effects of acute hyperinsulinemia on bone metabolism.
Article in Endocrine connections, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Prevalence and Associated Risk Factors of Osteoporosis in Community-Dwelling Older Adults in China: A Cross-Sectional Study of 2533 Participants.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- A Review of the Relationship Between Insulin and Bone Health.Biomedicines · 2025Review
- Effects of antidiabetic drugs on bone metabolism.Advances in laboratory medicine · 2024Article
- Article
- Plasma undercarboxylated osteocalcin dynamics with glycemic stress reflects insulin sensitivity and beta-cell function in humans with and without T2DM.Metabolism open · 2023Article
- Intermittent fasting and bone health: a bone of contention?The British journal of nutrition · 2023Review
- The Gut-Bone Axis in Diabetes.Current osteoporosis reports · 2023Review
- The impact of medication on osseointegration and implant anchorage in bone determined using removal torque-A review.Heliyon · 2022Article
- Bone Turnover Marker Profiling and Fracture Risk in Older Women: Fracture Risk from Age 75 to 90.Calcified tissue international · 2022Article
- Investigating the Effects of Diet-Induced Pre-Diabetes on the Functioning of Calcium-Regulating Organs in Male Sprague Dawley Rats: Effects on Selected Markers.Frontiers in endocrinology · 2022Article
- Evidence of impaired bone quality in men with type 1 diabetes: a cross-sectional study.Endocrine connections · 2021Article
- Disentangling the relationship between bone turnover and glucose homeostasis: A prospective, population-based twin study.Bone reports · 2021Article
- Evaluation of bone densitometry by dual-energy x-ray absorptiometry as a fracture prediction tool in women with chronic kidney disease.Bone reports · 2020Article
- Are there sex differences in the reaction of undercarboxylated osteocalcin to hypoglycemia?Physiological research · 2020Article
- Update on the Acute Effects of Glucose, Insulin, and Incretins on Bone Turnover In Vivo.Current osteoporosis reports · 2020Review
- Effects of Biliopancreatic Diversion on Bone Turnover Markers and Association with Hormonal Factors in Patients with Severe Obesity.Obesity surgery · 2019Observational
- Effect of Intravenous Glucose Tolerance Test on Bone Turnover Markers in Adults with Normal Glucose Tolerance.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin signaling in bone-forming osteoblasts stimulates bone formation and promotes the release of osteocalcin (OC) in mice. Only a few studies have assessed the direct effect of insulin on bone metabolism in humans. Here, we studied markers of bone metabolism in response to acute hyperinsulinemia in men and women. Thirty-three subjects from three separate cohorts (n=8, n=12 and n=13) participated in a euglycaemic hyperinsulinemic clamp study. Blood samples were collected before and at the end of infusions to determine the markers of bone formation (PINP, total OC, uncarboxylated form of OC (ucOC)) and resorption (CTX, TRAcP5b). During 4 h insulin infusion (40 mU/m(2) per min, low insulin), CTX level decreased by 11% (P<0.05). High insulin infusion rate (72 mU/m(2) per min) for 4 h resulted in more pronounced decrease (-32%, P<0.01) whereas shorter insulin exposure (40 mU/m(2) per min for 2 h) had no effect (P=0.61). Markers of osteoblast activity remained unchanged during 4 h insulin, but the ratio of uncarboxylated-to-total OC decreased in response to insulin (P<0.05 and P<0.01 for low and high insulin for 4 h respectively). During 2 h low insulin infusion, both total OC and ucOC decreased significantly (P<0.01 for both). In conclusion, insulin decreases bone resorption and circulating levels of total OC and ucOC. Insulin has direct effects on bone metabolism in humans and changes in the circulating levels of bone markers can be seen within a few hours after administration of insulin.
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