ArticleScientific reports2015
Targeted disruption of a single sex pheromone receptor gene completely abolishes in vivo pheromone response in the silkmoth.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.bioRxiv : the preprint server for biology · 2025Article
- Gustatory receptors interact with the serotonin pathway to regulate silkmoth stereotyped courtship behavior.BMC biology · 2025Article
- A covalent recognition strategy enables conspecific mate identification.bioRxiv : the preprint server for biology · 2025Article
- Odorant receptors for floral- and plant-derived volatiles in the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae).PloS one · 2024Article
- Pheromone Receptor Knock-Out Affects Pheromone Detection and Brain Structure in a Moth.Biomolecules · 2022Article
- Expanding the Toolkit for Genome Editing in a Disease Vector,The CRISPR journal · 2021Article
- Catching plague locusts with their own scent.Nature · 2020Article
- Regulation of olfactory-based sex behaviors in the silkworm by genes in the sex-determination cascade.PLoS genetics · 2020Article
- An Orphan Pheromone Receptor Affects the Mating Behavior ofFrontiers in physiology · 2020Article
- In vivo functional characterisation of pheromone binding protein-1 in the silkmoth, Bombyx mori.Scientific reports · 2018Article
- Access to the odor world: olfactory receptors and their role for signal transduction in insects.Cellular and molecular life sciences : CMLS · 2018Review
- Insect Pheromone Receptors - Key Elements in Sensing Intraspecific Chemical Signals.Frontiers in cellular neuroscience · 2018Review
- Refinement of ectopic protein expression through the GAL4/UAS system in Bombyx mori: application to behavioral and developmental studies.Scientific reports · 2017Article
- Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents.Frontiers in microbiology · 2017Review
- The Evolving Neural and Genetic Architecture of Vertebrate Olfaction.Current biology : CB · 2016Review
- Comparison of research methods for functional characterization of insect olfactory receptors.Scientific reports · 2016Article
- Heritable genome editing with CRISPR/Cas9 induces anosmia in a crop pest moth.Scientific reports · 2016Article
- Identification and Characterization of Two "Sensory Neuron Membrane Proteins" (SNMPs) of the Desert Locust, Schistocerca gregaria (Orthoptera: Acrididae).Journal of insect science (Online) · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Male moths use species-specific sex pheromones to identify and orientate toward conspecific females. Odorant receptors (ORs) for sex pheromone substances have been identified as sex pheromone receptors in various moth species. However, direct in vivo evidence linking the functional role of these ORs with behavioural responses is lacking. In the silkmoth, Bombyx mori, female moths emit two sex pheromone components, bombykol and bombykal, but only bombykol elicits sexual behaviour in male moths. A sex pheromone receptor BmOR1 is specifically tuned to bombykol and is expressed in specialized olfactory receptor neurons (ORNs) in the pheromone sensitive long sensilla trichodea of male silkmoth antennae. Here, we show that disruption of the BmOR1 gene, mediated by transcription activator-like effector nucleases (TALENs), completely removes ORN sensitivity to bombykol and corresponding pheromone-source searching behaviour in male moths. Furthermore, transgenic rescue of BmOR1 restored normal behavioural responses to bombykol. Our results demonstrate that BmOR1 is required for the physiological and behavioural response to bombykol, demonstrating that it is the receptor that mediates sex pheromone responses in male silkmoths. This study provides the first direct evidence that a member of the sex pheromone receptor family in moth species mediates conspecific sex pheromone information for sexual behaviour.
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