ArticlePloS one2015
Septic Shock in Advanced Age: Transcriptome Analysis Reveals Altered Molecular Signatures in Neutrophil Granulocytes.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Screening of core genes prognostic for sepsis and construction of a ceRNA regulatory network.BMC medical genomics · 2023Pooled it
- Mechanism of sepsis regulation by ELANE via macrophage polarization.Scientific reports · 2025Article
- S100P is a core gene for diagnosing and predicting the prognosis of sepsis.Scientific reports · 2025Article
- Identification of prognostic biomarkers of sepsis and construction of ceRNA regulatory networks.Scientific reports · 2025Article
- The intricate pathogenicity of Group AVirulence · 2024Review
- Identification of four mitochondria-related genes in sepsis based on RNA sequencing technology.BMC immunology · 2024Observational
- Article
- Article
- Transcriptome analysis of six tissues obtained post-mortem from sepsis patients.Journal of cellular and molecular medicine · 2023Article
- Proteomics Combined with RNA Sequencing to Screen Biomarkers of Sepsis.Infection and drug resistance · 2022Article
- Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.Molecular medicine (Cambridge, Mass.) · 2020Article
- Neutrophils in community-acquired pneumonia: parallels in dysfunction at the extremes of age.Thorax · 2020Review
- Short-Term Effects of Sepsis and the Impact of Aging on the Transcriptional Profile of Different Brain Regions.Inflammation · 2019Article
- Article
- To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps.Cell death and differentiation · 2019Review
- Group AMicrobiology spectrum · 2019Article
- Autophagy in Neutrophils: From Granulopoiesis to Neutrophil Extracellular Traps.Frontiers in cell and developmental biology · 2018Review
- Article
- Insights into the Function of Long Noncoding RNAs in Sepsis Revealed by Gene Co-Expression Network Analysis.Non-coding RNA · 2017Article
- Septic Shock and the Aging Process: A Molecular Comparison.Frontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is one of the highest causes of mortality in hospitalized people and a common complication in both surgical and clinical patients admitted to hospital for non-infectious reasons. Sepsis is especially common in older people and its incidence is likely to increase substantially as a population ages. Despite its increased prevalence and mortality in older people, immune responses in the elderly during septic shock appear similar to that in younger patients. The purpose of this study was to conduct a genome-wide gene expression analysis of circulating neutrophils from old and young septic patients to better understand how aged individuals respond to severe infectious insult. We detected several genes whose expression could be used to differentiate immune responses of the elderly from those of young people, including genes related to oxidative phosphorylation, mitochondrial dysfunction and TGF-β signaling, among others. Our results identify major molecular pathways that are particularly affected in the elderly during sepsis, which might have a pivotal role in worsening clinical outcomes compared with young people with sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.