ArticleEnvironmental health perspectives2016
Paired Serum and Urine Concentrations of Biomarkers of Diethyl Phthalate, Methyl Paraben, and Triclosan in Rats.
Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Hazards of diethyl phthalate (DEP) exposure: A systematic review of animal toxicology studies.Environment international · 2020Pooled it
- Pooled it
- Assessment of Phthalate Esters and Physiological Biomarkers in Bottlenose Dolphins (Animals : an open access journal from MDPI · 2024Article
- Parabens and bisphenol A and its structural analogues in over-the-counter medicines from China.Environmental science and pollution research international · 2021Article
- A novel study evaluation strategy in the systematic review of animal toxicology studies for human health assessments of environmental chemicals.Environment international · 2020Review
- Gene expression profiles for low-dose exposure to diethyl phthalate in rodents and humans: a translational study with implications for breast carcinogenesis.Scientific reports · 2020Article
- Fetal growth in environmental epidemiology: mechanisms, limitations, and a review of associations with biomarkers of non-persistent chemical exposures during pregnancy.Environmental health : a global access science source · 2019Review
- Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment: DiMoPEx-project is designed to determine the impacts of environmental exposure on human health.Journal of occupational medicine and toxicology (London, England) · 2018Review
- Developmental toxicity assessment of common excipients using a stem cell-based in vitro morphogenesis model.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2017Article
- A new method to study the change of miRNA-mRNA interactions due to environmental exposures.Bioinformatics (Oxford, England) · 2017Article
- An Integrated Experimental Design for the Assessment of Multiple Toxicological End Points in Rat Bioassays.Environmental health perspectives · 2017Article
- Exposure to bisphenol A is directly associated with inflammation in healthy Korean adults.Environmental science and pollution research international · 2017Article
- Changes in mammary histology and transcriptome profiles by low-dose exposure to environmental phenols at critical windows of development.Environmental research · 2017Article
- Differential effects on adiposity and serum marker of bone formation by post-weaning exposure to methylparaben and butylparaben.Environmental science and pollution research international · 2016Article
- Effect of postnatal low-dose exposure to environmental chemicals on the gut microbiome in a rodent model.Microbiome · 2016Article
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Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundExposure to environmental chemicals, including phthalates and phenols such as parabens and triclosan, is ubiquitous within the U.S. general population.
objectiveThis proof-of-concept rodent study examined the relationship between oral doses of three widely used personal care product ingredients [diethyl phthalate (DEP), methyl paraben (MPB), and triclosan] and urine and serum concentrations of their respective biomarkers.
methodsUsing female Sprague-Dawley rats, we carried out two rounds of experiments with oral gavage doses selected in accordance with no observed adverse effect levels (NOAELs) derived from previous studies: 1,735 (DEP), 1,050 (MPB), 50 (triclosan) mg/kg/day. Administered doses ranged from 0.005 to 173 mg/kg/day, 10-100,000 times below the NOAEL for each chemical. Controls for the MPB and triclosan experiments were animals treated with olive oil (vehicle) only; controls for the DEP serum experiments were animals treated with the lowest doses of MPB and triclosan. Doses were administered for 5 days with five rats in each treatment group. Urine and blood serum, collected on the last day of exposure, were analyzed for biomarkers. Relationships between oral dose and biomarker concentrations were assessed using linear regression.
resultsBiomarkers were detected in all control urine samples at parts-per-billion levels, suggesting a low endemic environmental exposure to the three chemicals that could not be controlled even with all of the precautionary measures undertaken. Among the exposed animals, urinary concentrations of all three biomarkers were orders of magnitude higher than those in serum. A consistently positive linear relationship between oral dose and urinary concentration was observed (R2 > 0.80); this relationship was inconsistent in serum.
conclusionsOur study highlights the importance of carefully considering the oral dose used in animal experiments and provides useful information in selecting doses for future studies. CITATION: Teitelbaum SL, Li Q, Lambertini L, Belpoggi F, Manservisi F, Falcioni L, Bua L, Silva MJ, Ye X, Calafat AM, Chen J. 2016. Paired serum and urine concentrations of biomarkers of diethyl phthalate, methyl paraben, and triclosan in rats. Environ Health Perspect 124:39-45; http://dx.doi.org/10.1289/ehp.1409586.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.