Evidence map›Paper›PMID 26047051›Full record

ArticleScientific reports2015

In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography.

Jianhua Wang, Ayman Aljohani, Teresia Carreon, Giovanni Gregori, Sanjoy K Bhattacharya

Abstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Endogenous ocular lipids as potential modulators of intraocular pressure.Journal of cellular and molecular medicine · 2020
    Article
  4. Review
  5. Article
  6. Article
  7. Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jianhua WangBascom Palmer Eye Institute, University of Miami, Miami, Florida, 33136.
Ayman AljohaniBascom Palmer Eye Institute, University of Miami, Miami, Florida, 33136.
Teresia CarreonBascom Palmer Eye Institute, University of Miami, Miami, Florida, 33136.
Giovanni GregoriBascom Palmer Eye Institute, University of Miami, Miami, Florida, 33136.
Sanjoy K BhattacharyaBascom Palmer Eye Institute, University of Miami, Miami, Florida, 33136.

Funding

TRABECULAR MESHWORK PROTEINS IN GLAUCOMAR01EY016112 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BHATTACHARYA, SANJOY K · 2006 to 2016
$3.7M
Retina/RPE genes altered in aging as candidates for AMDF32EY014085 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZAREPARSI, SEPIDEH · 2002 to 2004
$143k
NEI NIH HHS EY016112NEI NIH HHS EY016112S1NEI NIH HHS EY14085NEI NIH HHS F32 EY014085NEI NIH HHS R01 EY016112
6 · The paper itself

Abstract

The expression of cochlin in the trabecular meshwork (TM) precedes the clinical glaucoma symptoms in DBA/2J mice. The ability to quantify cochlin in the local tissue (TM) offers potential diagnostic and prognostic values. We present two (spectroscopic and magnetomotive) optical coherence tomography (OCT) approaches for in vivo cochlin quantification in a periodic manner. The cochlin-antibody OCT signal remains stable for up to 24 hours as seen at 3.5 hours after injection allowing for repeated quantification in the living mouse eyes.

Indexed as

Tomography, Optical CoherenceAnimalsCells, CulturedDisease Models, AnimalExtracellular Matrix ProteinsEyeFemaleGlaucomaHumansImmunohistochemistryIntraocular PressureMaleMiceMice, Inbred DBAMicroscopy, ConfocalMiddle AgedCOCH protein, humanCoch protein, mouseExtracellular Matrix Proteins

Identifiers

PMID26047051
PMCPMC4457137

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.