Evidence map›Paper›PMID 26046965›Full record

ArticleThe Journal of clinical endocrinology and metabolism2015

Association of Sleep Duration and Quality With Alterations in the Hypothalamic-Pituitary Adrenocortical Axis: The Multi-Ethnic Study of Atherosclerosis (MESA).

Cecilia Castro-Diehl, Ana V Diez Roux, Susan Redline, Teresa Seeman, Sandi E Shrager, Steven Shea

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Mechanisms Linking Insomnia and Cardiometabolic Disease Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cecilia Castro-DiehlDepartment of Medicine (C.C.-D., S. S.), Columbia University College of Physicians and Surgeons, New York, New York 10032; Department of Epidemiology (C.C.-D., S. S.), Mailman School of Public Health, Columbia University, New York, New York 10032; Department of Epidemiology and Biostatistics (A.V.D.R.), Drexel University School of Public Health, Philadelphia, Pennsylvania 19104; Departments of Medicine (S.R.), Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115; Department of Medicine/Geriatrics (T.S.), University of California, Los Angeles, Los Angeles, California 90095; and Department of Biostatistics (S. E. S.), University of Washington, Seattle, Washington 98115.
Ana V Diez RouxDepartment of Medicine (C.C.-D., S. S.), Columbia University College of Physicians and Surgeons, New York, New York 10032; Department of Epidemiology (C.C.-D., S. S.), Mailman School of Public Health, Columbia University, New York, New York 10032; Department of Epidemiology and Biostatistics (A.V.D.R.), Drexel University School of Public Health, Philadelphia, Pennsylvania 19104; Departments of Medicine (S.R.), Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115; Department of Medicine/Geriatrics (T.S.), University of California, Los Angeles, Los Angeles, California 90095; and Department of Biostatistics (S. E. S.), University of Washington, Seattle, Washington 98115.
Susan RedlineDepartment of Medicine (C.C.-D., S. S.), Columbia University College of Physicians and Surgeons, New York, New York 10032; Department of Epidemiology (C.C.-D., S. S.), Mailman School of Public Health, Columbia University, New York, New York 10032; Department of Epidemiology and Biostatistics (A.V.D.R.), Drexel University School of Public Health, Philadelphia, Pennsylvania 19104; Departments of Medicine (S.R.), Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115; Department of Medicine/Geriatrics (T.S.), University of California, Los Angeles, Los Angeles, California 90095; and Department of Biostatistics (S. E. S.), University of Washington, Seattle, Washington 98115.
Teresa SeemanDepartment of Medicine (C.C.-D., S. S.), Columbia University College of Physicians and Surgeons, New York, New York 10032; Department of Epidemiology (C.C.-D., S. S.), Mailman School of Public Health, Columbia University, New York, New York 10032; Department of Epidemiology and Biostatistics (A.V.D.R.), Drexel University School of Public Health, Philadelphia, Pennsylvania 19104; Departments of Medicine (S.R.), Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115; Department of Medicine/Geriatrics (T.S.), University of California, Los Angeles, Los Angeles, California 90095; and Department of Biostatistics (S. E. S.), University of Washington, Seattle, Washington 98115.
Sandi E ShragerDepartment of Medicine (C.C.-D., S. S.), Columbia University College of Physicians and Surgeons, New York, New York 10032; Department of Epidemiology (C.C.-D., S. S.), Mailman School of Public Health, Columbia University, New York, New York 10032; Department of Epidemiology and Biostatistics (A.V.D.R.), Drexel University School of Public Health, Philadelphia, Pennsylvania 19104; Departments of Medicine (S.R.), Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115; Department of Medicine/Geriatrics (T.S.), University of California, Los Angeles, Los Angeles, California 90095; and Department of Biostatistics (S. E. S.), University of Washington, Seattle, Washington 98115.
Steven SheaDepartment of Medicine (C.C.-D., S. S.), Columbia University College of Physicians and Surgeons, New York, New York 10032; Department of Epidemiology (C.C.-D., S. S.), Mailman School of Public Health, Columbia University, New York, New York 10032; Department of Epidemiology and Biostatistics (A.V.D.R.), Drexel University School of Public Health, Philadelphia, Pennsylvania 19104; Departments of Medicine (S.R.), Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115; Department of Medicine/Geriatrics (T.S.), University of California, Los Angeles, Los Angeles, California 90095; and Department of Biostatistics (S. E. S.), University of Washington, Seattle, Washington 98115.

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
ASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPSR01HL098433 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2010 to 2015
$8.2M
Socioeconimic Patterning of Inflammation and HemostasisR01HL076831 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ-ROUX, ANA V. · 2004 to 2007
$2.5M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1-TR-000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1-TR-001079NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS R01 HL076831NHLBI NIH HHS R01 HL098433
6 · The paper itself

Abstract

contextShort sleep duration and poor sleep quality are associated with cardiovascular outcomes. One mechanism proposed to explain this association is altered diurnal cortisol secretion.

objectiveThe objective of the study was to examine the associations of sleep duration and sleep quality with diurnal salivary cortisol levels.

designThis was a cross-sectional analysis using data from examination 5 (2010-2012) of the Multi-Ethnic Study of Atherosclerosis. Actigraphy-based measures of sleep duration and efficiency were collected over 7 days, and salivary cortisol samples were collected over 2 days from participants aged 54-93 years (n = 600 with analyzable data).

resultsShorter average sleep duration (<6 h/night) was associated with less pronounced late decline in cortisol [2.2% difference in slope; 95% confidence interval (CI) 0.8-3.7; P ≤ .01] and less pronounced wake-to-bed slope (2.2% difference; 95% CI 1.0-3.4; P ≤ .001) compared with longer sleep duration (≥6 h/night). Lower sleep efficiency (<85%) was associated with less pronounced early decline in cortisol (29.0% difference in slope; 95% CI 4.1-59.7; P < .05) compared with higher sleep efficiency (≥85%). Subjects reporting insomnia had a flatter cortisol awakening response (-16.1% difference in slope; 95% CI -34.6 to -0.1; P < .05) compared with those not reporting insomnia.

conclusionsShorter sleep duration, lower sleep efficiency, and insomnia are associated with alterations in diurnal cortisol levels consistent with changes in hypothalamic-pituitary-adrenal regulation.

Indexed as

ActigraphyAgedAged, 80 and overAtherosclerosisCross-Sectional StudiesEthnicityFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemSalivaSleepSleep Wake DisordersHydrocortisone

Identifiers

PMID26046965
PMCPMC4524997

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.