ArticleScientific reports2015
Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 75 citations in OpenAlex.
- Ecological Niche Differentiation Parallels Genomic Divergence of ThreeJournal of fungi (Basel, Switzerland) · 2026Article
- From natural laboratory to drug discovery: Chemical structures, bioactivities, and biosynthesis of meroterpenoids fromChinese herbal medicines · 2026Review
- First pathogenomic insights into Ganoderma ellipsoideum as an emerging causal agent of basal stem rot in oil palm.Scientific reports · 2025Article
- Morphogenesis, starvation, and light responses in a mushroom-forming fungus revealed by long-read sequencing and extensive expression profiling.Cell genomics · 2025Article
- Review
- Comparative Mitogenomics Provides Valuable Insights for the Phylogeny and New DNA Barcodes ofJournal of fungi (Basel, Switzerland) · 2024Article
- Whole-genome sequencing of Ganoderma boninense, the causal agent of basal stem rot disease in oil palm, via combined short- and long-read sequencing.Scientific reports · 2024Article
- Whole-genome sequencing and comparative genomic analyses of the medicinal fungus Sanguinoderma infundibulare in Ganodermataceae.G3 (Bethesda, Md.) · 2024Article
- Telomere-to-Telomere Genome Assembly of Tibetan Medicinal MushroomJournal of fungi (Basel, Switzerland) · 2023Article
- Combinatorial optimization and spatial remodeling of CYPs to control product profile.Metabolic engineering · 2023Article
- Unraveling the Polysaccharide Biosynthesis Potential ofJournal of fungi (Basel, Switzerland) · 2023Article
- Integrated omic profiling of the medicinal mushroom Inonotus obliquus under submerged conditions.BMC genomics · 2023Article
- Increasing the production of the bioactive compounds in medicinal mushrooms: an omics perspective.Microbial cell factories · 2023Review
- High-quality genome assembly and multi-omics analysis of pigment synthesis pathway inFrontiers in microbiology · 2023Article
- Comprehensive analysis of codon bias in 13Frontiers in microbiology · 2023Article
- Tandem expression of Ganoderma sinense sesquiterpene synthase and IDI promotes the production of gleenol in E. coli.Applied microbiology and biotechnology · 2022Article
- Comparative Mitogenomic Analysis Reveals Intraspecific, Interspecific Variations and Genetic Diversity of Medical FungusJournal of fungi (Basel, Switzerland) · 2022Article
- Phylogenomics and Comparative Genomics Highlight Specific Genetic Features inJournal of fungi (Basel, Switzerland) · 2022Article
- Characterization of γ-Cadinene Enzymes inACS omega · 2022Article
- Taxonomy and phylogeny ofFrontiers in microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungi have evolved powerful genomic and chemical defense systems to protect themselves against genetic destabilization and other organisms. However, the precise molecular basis involved in fungal defense remain largely unknown in Basidiomycetes. Here the complete genome sequence, as well as DNA methylation patterns and small RNA transcriptomes, was analyzed to provide a holistic overview of secondary metabolism and defense processes in the model medicinal fungus, Ganoderma sinense. We reported the 48.96 Mb genome sequence of G. sinense, consisting of 12 chromosomes and encoding 15,688 genes. More than thirty gene clusters involved in the biosynthesis of secondary metabolites, as well as a large array of genes responsible for their transport and regulation were highlighted. In addition, components of genome defense mechanisms, namely repeat-induced point mutation (RIP), DNA methylation and small RNA-mediated gene silencing, were revealed in G. sinense. Systematic bioinformatic investigation of the genome and methylome suggested that RIP and DNA methylation combinatorially maintain G. sinense genome stability by inactivating invasive genetic material and transposable elements. The elucidation of the G. sinense genome and epigenome provides an unparalleled opportunity to advance our understanding of secondary metabolism and fungal defense mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.