ArticlePloS one2015
In Situ OH Generation from O2- and H2O2 Plays a Critical Role in Plasma-Induced Cell Death.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 159 citations in OpenAlex.
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- A Comprehensive Review of Mitochondrial Complex I During Mammalian Oocyte Maturation.Genesis (New York, N.Y. : 2000) · 2025Review
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- Essentials and Pertinence of Cold Plasma in Essential Oils, Metal-Organic Frameworks and Agriculture.Food science & nutrition · 2024Review
- Cold Atmospheric Pressure Plasma-Activated Medium Modulates Cellular Functions of Human Mesenchymal Stem/Stromal Cells In Vitro.International journal of molecular sciences · 2024Article
- Effects of Non-Thermal Dielectric Barrier Discharge Plasma on Human Fibroblasts: A Narrative Review.Frontiers in dentistry · 2024Review
- Cold Atmospheric Plasma Jet Irradiation Decreases the Survival and the Expression of Oncogenic miRNAs of Oral Carcinoma Cells.International journal of molecular sciences · 2023Article
- Antioxidant and Immune-Related Implications of Minerals in COVID-19: A Possibility for Disease Prevention and Management.Antioxidants (Basel, Switzerland) · 2023Review
- Glutamine Deprivation Synergizes the Anticancer Effects of Cold Atmospheric Plasma on Esophageal Cancer Cells.Molecules (Basel, Switzerland) · 2023Article
- Cellular-level insight into biointerface: From surface charge modulation to boosted photocatalytic oxidative disinfection.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2023Article
- Reduction of Viral and Bacterial Activity by Using a Self-Powered Variable-Frequency Electrical Stimulation Device.Micromachines · 2023Article
- Biophysical evaluation of treating adipose tissue-derived stem cells using non-thermal atmospheric pressure plasma.Scientific reports · 2022Article
- The Effect of Gap Distance between a Pin and Water Surface on the Inactivation ofInternational journal of molecular sciences · 2022Article
- Cold atmospheric plasmas target breast cancer stemness via modulating AQP3-19Y mediated AQP3-5K and FOXO1 K48-ubiquitination.International journal of biological sciences · 2022Article
- Cold atmospheric plasma for preventing infection of viruses that use ACE2 for entry.Theranostics · 2022Article
- Current approaches for the exploration of antimicrobial activities of nanoparticles.Science and technology of advanced materials · 2021Review
- Biomolecules as Model Indicators ofFrontiers in physics · 2021Article
- Plasma-activated medium as adjuvant therapy for lung cancer with malignant pleural effusion.Scientific reports · 2020Article
- Is copper beneficial for COVID-19 patients?Medical hypotheses · 2020Article
- Quantitation of the ROS production in plasma and radiation treatments of biotargets.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen and nitrogen species produced by cold atmospheric plasma (CAP) are considered to be the most important species for biomedical applications, including cancer treatment. However, it is not known which species exert the greatest biological effects, and the nature of their interactions with tumor cells remains ill-defined. These questions were addressed in the present study by exposing human mesenchymal stromal and LP-1 cells to reactive oxygen and nitrogen species produced by CAP and evaluating cell viability. Superoxide anion (O2-) and hydrogen peroxide (H2O2) were the two major species present in plasma, but their respective concentrations were not sufficient to cause cell death when used in isolation; however, in the presence of iron, both species enhanced the cell death-inducing effects of plasma. We propose that iron containing proteins in cells catalyze O2- and H2O2 into the highly reactive OH radical that can induce cell death. The results demonstrate how reactive species are transferred to liquid and converted into the OH radical to mediate cytotoxicity and provide mechanistic insight into the molecular mechanisms underlying tumor cell death by plasma treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.