Evidence map›Paper›PMID 26046643›Full record

ArticleMolecular cell2015

PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1.

Peter J Siska, Jeffrey C Rathmell

Open access · bronzeAbstract readComment
In one paragraph

Article in Molecular cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. The role of SLC transporters for brain health and disease.Cellular and molecular life sciences : CMLS · 2021
    Review
  7. Article
  8. Article
  9. Reversing T-cell Dysfunction and Exhaustion in Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016
    Review
  10. GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters.Protein science : a publication of the Protein Society · 2016
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peter J SiskaDepartment of Pharmacology and Cancer Biology, Department of Immunology, Duke Molecular Physiology Institute, Duke University, Durham, NC 27710, USA.
Jeffrey C RathmellDepartment of Pharmacology and Cancer Biology, Department of Immunology, Duke Molecular Physiology Institute, Duke University, Durham, NC 27710, USA. Electronic address: jeff.rathmell@duke.edu.
Duke University · US

Funding

Exploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory diseaseR01DK105550 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey C Rathmell · 2015 to 2026
$4.7M
NIDDK NIH HHS R01 DK105550NIDDK NIH HHS R01DK105550
6 · The paper itself

Abstract

In this issue, Lee et al. (2015) show that PKC directly phosphorylates the glucose transporter Glut1, in order to promote glucose uptake in response to growth factor signaling.

Indexed as

AnimalsCarbohydrate Metabolism, Inborn ErrorsGlucose Transporter Type 1HumansMonosaccharide Transport ProteinsProtein Kinase C-alphaGlucose Transporter Type 1Monosaccharide Transport ProteinsProtein Kinase C-alpha

Identifiers

PMID26046643
PMCPMC4704109
OpenAlexW1562700413

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.