ArticlePLoS computational biology2015
Particle Simulation of Oxidation Induced Band 3 Clustering in Human Erythrocytes.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Autoantibodies to Extracellular Erythrocyte Band 3 Epitopes Are Associated With Anemia in Plasmodium vivax Infection.American journal of hematology · 2026Article
- Temperature as a Regulator of Red Blood Cell Fate: From Membrane Dynamics to Cellular Clearance.Medical sciences (Basel, Switzerland) · 2026Review
- N-Acetylcysteine Attenuates Oxidative Stress and Preserves Red Blood Cell Quality During Whole Blood Storage.Antioxidants (Basel, Switzerland) · 2026Article
- Redox Homeostasis in Red Blood Cells: From Molecular Mechanisms to Antioxidant Strategies.Current issues in molecular biology · 2025Review
- The Effect of a Secondary Stressor on the Morphology and Membrane Structure of an Already Challenged Maternal and Foetal Red Blood Cell Population.International journal of molecular sciences · 2025Article
- Review
- Aging Injury Impairs Structural Properties and Cell Signaling in Human Red Blood Cells; Açaì Berry Is a Keystone.Antioxidants (Basel, Switzerland) · 2023Article
- Towards modelling emergence in plant systems.Quantitative plant biology · 2023Article
- Antioxidant Activity of Quercetin in a HInternational journal of molecular sciences · 2022Article
- Morphometric and Nanomechanical Features of Erythrocytes Characteristic of Early Pregnancy Loss.International journal of molecular sciences · 2022Article
- Myostatin Knockout Limits Exercise-Induced Reduction in Bovine Erythrocyte Oxidative Stress by Enhancing the Efficiency of the Pentose Phosphate Pathway.Animals : an open access journal from MDPI · 2022Article
- d-Galactose induced early aging in human erythrocytes: Role of band 3 protein.Journal of cellular physiology · 2022Article
- Can repurposing drugs play a role in malaria control?The Journal of experimental medicine · 2021Article
- Erythrocytes: Central Actors in Multiple Scenes of Atherosclerosis.International journal of molecular sciences · 2021Review
- Current advances in nanomaterials affecting morphology, structure, and function of erythrocytes.RSC advances · 2021Review
- Bisphenol A and Bisphenol S Oxidative Effects in Sheep Red Blood Cells: AnBioMed research international · 2021Article
- Microvesicle Formation Induced by Oxidative Stress in Human Erythrocytes.Antioxidants (Basel, Switzerland) · 2020Article
- Oxidation Impacts the Intracellular Signaling Machinery in Hematological Disorders.Antioxidants (Basel, Switzerland) · 2020Review
- Human erythrocyte band 3 is a host receptor forBlood · 2019Article
- Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator.Nature communications · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress mediated clustering of membrane protein band 3 plays an essential role in the clearance of damaged and aged red blood cells (RBCs) from the circulation. While a number of previous experimental studies have observed changes in band 3 distribution after oxidative treatment, the details of how these clusters are formed and how their properties change under different conditions have remained poorly understood. To address these issues, a framework that enables the simultaneous monitoring of the temporal and spatial changes following oxidation is needed. In this study, we established a novel simulation strategy that incorporates deterministic and stochastic reactions with particle reaction-diffusion processes, to model band 3 cluster formation at single molecule resolution. By integrating a kinetic model of RBC antioxidant metabolism with a model of band 3 diffusion, we developed a model that reproduces the time-dependent changes of glutathione and clustered band 3 levels, as well as band 3 distribution during oxidative treatment, observed in prior studies. We predicted that cluster formation is largely dependent on fast reverse reaction rates, strong affinity between clustering molecules, and irreversible hemichrome binding. We further predicted that under repeated oxidative perturbations, clusters tended to progressively grow and shift towards an irreversible state. Application of our model to simulate oxidation in RBCs with cytoskeletal deficiency also suggested that oxidation leads to more enhanced clustering compared to healthy RBCs. Taken together, our model enables the prediction of band 3 spatio-temporal profiles under various situations, thus providing valuable insights to potentially aid understanding mechanisms for removing senescent and premature RBCs.
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