ArticleApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine2015
Fully-automated synthesis of 16β-(18)F-fluoro-5α-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer.
Article in Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- State of the art procedures towards reactive [EJNMMI radiopharmacy and chemistry · 2023Review
- Article
- Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production.Journal of visualized experiments : JoVE · 2018Article
- Production of diverse PET probes with limited resources: 24Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Evaluation of Castration-Resistant Prostate Cancer with Androgen Receptor-Axis Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016Article
- Fully automated synthesis of [(18) F]fluoro-dihydrotestosterone ([(18) F]FDHT) using the FlexLab module.Journal of labelled compounds & radiopharmaceuticals · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Noninvasive in vivo imaging of androgen receptor (AR) levels with positron emission tomography (PET) is becoming the primary tool in prostate cancer detection and staging. Of the potential (18)F-labeled PET tracers, (18)F-FDHT has clinically shown to be of highest diagnostic value. We demonstrate the first automated synthesis of (18)F-FDHT by adapting the conventional manual synthesis onto the fully-automated ELIXYS radiosynthesizer. Clinically-relevant amounts of (18)F-FDHT were synthesized on ELIXYS in 90 min with decay-corrected radiochemical yield of 29±5% (n=7). The specific activity was 4.6 Ci/µmol (170 GBq/µmol) at end of formulation with a starting activity of 1.0 Ci (37 GBq). The formulated (18)F-FDHT yielded sufficient activity for multiple patient doses and passed all quality control tests required for routine clinical use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.