ArticleScientific reports2015
Neonatal exposure to sevoflurane may not cause learning and memory deficits and behavioral abnormality in the childhood of Cynomolgus monkeys.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Pre-clinical and clinical trials for anesthesia in neonates: gaps and future directions.Pediatric radiology · 2024Review
- Effects of Anesthesia on Cerebral Blood Flow and Functional Connectivity of Nonhuman Primates.Veterinary sciences · 2022Review
- Review
- Differential Effects of Sevoflurane Exposure on Long-Term Fear Memory in Neonatal and Adult Rats.Molecular neurobiology · 2022Article
- General Anesthesia in the First 36 Months of Life.Deutsches Arzteblatt international · 2021Article
- Analgesia for fetal pain during prenatal surgery: 10 years of progress.Pediatric research · 2021Review
- Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment.Neurobiology of learning and memory · 2019Review
- Relevance of experimental paradigms of anesthesia induced neurotoxicity in the mouse.PloS one · 2019Article
- Early Developmental Exposure to Repetitive Long Duration of Midazolam Sedation Causes Behavioral and Synaptic Alterations in a Rodent Model of Neurodevelopment.Journal of neurosurgical anesthesiology · 2019Article
- Article
- General Anesthesia and Young Brain: What is New?Journal of neurosurgical anesthesiology · 2018Review
- Propofol and sevoflurane combined with remifentanil on the pain index, inflammatory factors and postoperative cognitive function of spine fracture patients.Experimental and therapeutic medicine · 2018Article
- Postoperative Delirium, Learning, and Anesthetic Neurotoxicity: Some Perspectives and Directions.Frontiers in neurology · 2018Article
- Ferroptosis Contributes to Isoflurane Neurotoxicity.Frontiers in molecular neuroscience · 2018Article
- Anesthetic management of primary hyperparathyroidism during pregnancy: A case report.Medicine · 2017Article
- Effects of short-term exposure to sevoflurane on the survival, proliferation, apoptosis, and differentiation of neural precursor cells derived from human embryonic stem cells.Journal of anesthesia · 2017Article
- Visual recognition memory is impaired in rhesus monkeys repeatedly exposed to sevoflurane in infancy.British journal of anaesthesia · 2017Article
- Decrease of glial cell-derived neurotrophic factor contributes to anesthesia- and surgery-induced learning and memory dysfunction in neonatal rats.Journal of molecular medicine (Berlin, Germany) · 2017Article
- Hyperbaric oxygen preconditioning improves postoperative cognitive dysfunction by reducing oxidant stress and inflammation.Neural regeneration research · 2017Review
- Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques.Anesthesiology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Results of animal studies have raised a significant concern that commonly used general anesthetics may induce neurotoxicity in children. It may be difficult to resolve this concern with human studies because randomizing children only for testing anesthetic toxicity may not be feasible. We randomized 6-day old male Cynomolgus monkeys to receive or not to receive sevoflurane anesthesia at surgical plane for 5 h. Sevoflurane is the most commonly used general anesthetic in children in the U.S.A. Here, we showed that sevoflurane anesthesia did not affect the behavior evaluated by holding cage method when the monkeys were 3 and 7 months old. However, there was an age-dependent decrease in the frequency of stress events and environmental exploration behavior during the test. Sevoflurane also did not affect the learning and memory of the monkeys when they were assessed from the age of 7 months. Finally, sevoflurane did not affect the expression of multiple neuron-specific proteins in the hippocampus and cerebral cortex of 10-month old monkeys after all behavioral and cognitive tests were completed. These results suggest that exposure of neonatal monkey to sevoflurane may not affect cognition, behavior and neuronal structures in childhood, indicating the safety of sevoflurane anesthesia in children.
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