ArticleCell2015
Forget the Parents: Epigenetic Reprogramming in Human Germ Cells.
Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Germline and Embryonic Mechanisms in the Epigenetic Inheritance of Neurodevelopmental and Cognitive Traits in Mammals.Biomolecules · 2026Review
- The road to restore male fertility using in vitro-derived germ cells.Human reproduction update · 2026Review
- High resolution multi-scale profiling of embryonic germ cell-like cell derivation reveals pluripotent state transitions in humans.Stem cell reports · 2026Article
- Stronger Parental Than Temperature Effects on Methylation in Juvenile Brown Trout (Ecology and evolution · 2025Article
- Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development.Nature communications · 2025Article
- Stable Transmission of DNA Methylation Epimutations from Germlines to the Liver and Their Association with Fatty Liver Disease in Medaka.Research square · 2025Article
- Dynamic methylation pattern of H19DMR and KvDMR1 in bovine oocytes and preimplantation embryos.Journal of assisted reproduction and genetics · 2024Article
- Source cell-type epigenetic memory persists in induced pluripotent cells but is lost in subsequently derived germline cells.Frontiers in cell and developmental biology · 2024Article
- Epigenetic Reprogramming inCells · 2023Review
- The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome?Human genomics · 2023Article
- Development, promotion, and application of online OvAge calculator based on the WeChat applet: Clinical prediction model research.PloS one · 2023Article
- Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis.Clinical epigenetics · 2022Article
- DNA methylation in newborns conceived by assisted reproductive technology.Nature communications · 2022Article
- Roles of Spermatogonial Stem Cells in Spermatogenesis and Fertility Restoration.Frontiers in endocrinology · 2022Review
- Increased de novo DNA Methylation Enzymes in Sperm of Individuals with Varicocele.Cell journal · 2021Article
- An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies.Clinical epigenetics · 2021Article
- The Role of DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish.Genomics, proteomics & bioinformatics · 2021Article
- Epigenetics of Male Infertility: The Role of DNA Methylation.Frontiers in cell and developmental biology · 2021Review
- The histone demethylase KDM2B regulates human primordial germ cell-like cells specification.International journal of biological sciences · 2021Article
- The Impact of DNA Methylation Dynamics on the Mutation Rate During Human Germline Development.G3 (Bethesda, Md.) · 2020Article
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Authors and funding
2 authors.
Funding
Abstract
Epigenetic reprogramming in the germline resets genomic potential and erases epigenetic memory. Three studies by Gkountela et al., Guo et al., and Tang et al. analyze the transcriptional and epigenetic landscape of human primordial germ cells, revealing a unique transcriptional network and progressive and conserved global erasure of DNA methylation.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.