Trial reportMayo Clinic proceedings2015
Motor and Nonmotor Circuitry Activation Induced by Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson Disease: Intraoperative Functional Magnetic Resonance Imaging for Deep Brain Stimulation.
Trial report in Mayo Clinic proceedings, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01809613 (Functional Magnetic Resonance Imaging), which is not on this map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Functional Magnetic Resonance Imaging (fMRI) During Deep Brain Stimulation (DBS) to Treat Parkinson's Disease
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- One Side or Two? A Systematic Review of Deep Brain Stimulation Approaches in Movement Disorders.Movement disorders clinical practice · 2025Pooled it
- Use of Functional MRI in Deep Brain Stimulation in Parkinson's Diseases: A Systematic Review.Frontiers in neurology · 2022Pooled it
- Cognitive Changes following Bilateral Deep Brain Stimulation of Subthalamic Nucleus in Parkinson's Disease: A Meta-Analysis.BioMed research international · 2016Pooled it
- Subthalamic Nucleus Deep Brain Stimulation Modulates 2 Distinct Neurocircuits.Annals of neurology · 2020Trial
- The Impact of Mirth-Inducing Ventral Striatal Deep Brain Stimulation on Functional and Effective Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2017Trial
- Circuit response to neuromodulation characterized with simultaneous deep brain stimulation and precision neuroimaging in humans.Nature neuroscience · 2026Article
- Technical considerations of functional MRI in deep brain stimulation: recent advances and future perspectives.NeuroImage · 2026Review
- Human cerebrospinal fluid net flow enhanced by respiration during the awake state.Nature communications · 2025Article
- Molecular glucose imaging reveals functional brain reconfiguration by subthalamic deep brain stimulation in Parkinsonian rats.Translational neurodegeneration · 2025Article
- Engaging dystonia networks with subthalamic stimulation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multimodal neuroimaging to characterize symptom-specific networks in movement disorders.NPJ Parkinson's disease · 2024Review
- Engaging dystonia networks with subthalamic stimulation.medRxiv : the preprint server for health sciences · 2024Article
- Modulation of Cerebellar Oscillations with Subthalamic Stimulation in Patients with Parkinson's Disease.Journal of Parkinson's disease · 2024Article
- Does Impaired Plantar Cutaneous Vibration Perception Contribute to Axial Motor Symptoms in Parkinson's Disease? Effects of Medication and Subthalamic Nucleus Deep Brain Stimulation.Brain sciences · 2023Article
- Deep brain stimulation of the subthalamic nucleus in severe Parkinson's disease: relationships between dual-contact topographic setting and 1-year worsening of speech and gait.Acta neurochirurgica · 2023Observational
- Evolving characterization of the human hyperdirect pathway.Brain structure & function · 2023Review
- Nomogram to Predict Cognitive State Improvement after Deep Brain Stimulation for Parkinson's Disease.Brain sciences · 2022Article
- Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition.Scientific reports · 2022Article
- The Supplementary Motor Complex in Parkinson's Disease.Journal of movement disorders · 2022Article
- Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
objectiveTo test the hypothesis suggested by previous studies that subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with Parkinson disease would affect the activity of motor and nonmotor networks, we applied intraoperative functional magnetic resonance imaging (fMRI) to patients receiving DBS. PATIENTS AND
methodsTen patients receiving STN DBS for Parkinson disease underwent intraoperative 1.5-T fMRI during high-frequency stimulation delivered via an external pulse generator. The study was conducted between January 1, 2013, and September 30, 2014.
resultsWe observed blood oxygen level-dependent (BOLD) signal changes (false discovery rate <0.001) in the motor circuitry (including the primary motor, premotor, and supplementary motor cortices; thalamus; pedunculopontine nucleus; and cerebellum) and in the limbic circuitry (including the cingulate and insular cortices). Activation of the motor network was observed also after applying a Bonferroni correction (P<.001) to the data set, suggesting that across patients, BOLD changes in the motor circuitry are more consistent compared with those occurring in the nonmotor network.
conclusionThese findings support the modulatory role of STN DBS on the activity of motor and nonmotor networks and suggest complex mechanisms as the basis of the efficacy of this treatment modality. Furthermore, these results suggest that across patients, BOLD changes in the motor circuitry are more consistent than those in the nonmotor network. With further studies combining the use of real-time intraoperative fMRI with clinical outcomes in patients treated with DBS, functional imaging techniques have the potential not only to elucidate the mechanisms of DBS functioning but also to guide and assist in the surgical treatment of patients affected by movement and neuropsychiatric disorders.
trial registrationclinicaltrials.gov Identifier: NCT01809613.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.