Evidence map›Paper›PMID 26046282›Full record

ArticleMaterials science & engineering. C, Materials for biological applications2015

Hydrophilic polyurethane matrix promotes chondrogenesis of mesenchymal stem cells.

Sandeep M Nalluri, G Rajesh Krishnan, Calvin Cheah, Ayesha Arzumand, Yuan Yuan, Caley A Richardson, Shuying Yang, Debanjan Sarkar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials science & engineering. C, Materials for biological applications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Polyurethane Microgel Based Microtissue: Interface-Guided Assembly and Spreading.Langmuir : the ACS journal of surfaces and colloids · 2017
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sandeep M NalluriDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
G Rajesh KrishnanDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Calvin CheahDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Ayesha ArzumandDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Yuan YuanDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Caley A RichardsonDepartment of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Shuying YangDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.
Debanjan SarkarDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA; Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA. Electronic address: debanjan@buffalo.edu.
University at Buffalo, State University of New York · US

Funding

Regulation of (Ca2+)i oscillation and osteoclast differentiation by RGS12K08AR055678 · NIAMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI YANG, SHUYING · 2008 to 2010
$311k
The role of IFT80 in bone formationR03AR061052 · NIAMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI YANG, SHUYING · 2012 to 2014
$232k
NIAMS NIH HHS K08 AR055678NIAMS NIH HHS R03 AR061052
6 · The paper itself

Abstract

Segmental polyurethanes exhibit biphasic morphology and can control cell fate by providing distinct matrix guided signals to increase the chondrogenic potential of mesenchymal stem cells (MSCs). Polyethylene glycol (PEG) based hydrophilic polyurethanes can deliver differential signals to MSCs through their matrix phases where hard segments are cell-interactive domains and PEG based soft segments are minimally interactive with cells. These coordinated communications can modulate cell-matrix interactions to control cell shape and size for chondrogenesis. Biphasic character and hydrophilicity of polyurethanes with gel like architecture provide a synthetic matrix conducive for chondrogenesis of MSCs, as evidenced by deposition of cartilage-associated extracellular matrix. Compared to monophasic hydrogels, presence of cell interactive domains in hydrophilic polyurethanes gels can balance cell-cell and cell-matrix interactions. These results demonstrate the correlation between lineage commitment and the changes in cell shape, cell-matrix interaction, and cell-cell adhesion during chondrogenic differentiation which is regulated by polyurethane phase morphology, and thus, represent hydrophilic polyurethanes as promising synthetic matrices for cartilage regeneration.

Indexed as

ChondrogenesisCartilageCell CommunicationCell DifferentiationCells, ImmobilizedExtracellular MatrixHumansHydrogelsHydrophobic and Hydrophilic InteractionsMesenchymal Stem CellsPolyethylene GlycolsPolyurethanesHydrogelsPolyethylene GlycolsPolyurethanesChondrogenic differentiationGelMesenchymal stem cellPolyurethane

Identifiers

PMID26046282
PMCPMC5201126
OpenAlexW304413475

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.