Evidence map›Paper›PMID 26046241›Full record

ReviewClinical therapeutics2015

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation.

Anastasia I Petra, Smaro Panagiotidou, Erifili Hatziagelaki, Julia M Stewart, Pio Conti, Theoharis C Theoharides

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03279224 (A Randomized Controlled Trial of the Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Bipolar Disorder), which is not on this map. Cited by 282 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
282citing papers in PubMed, 5 pooled it
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03279224 phase2 / phase3unknown statusnot on this mapstarted 2018, after this paper: background citation

A Randomized Controlled Trial of the Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Bipolar Disorder

TypeinterventionalSponsorValerie TaylorRan2018 to 2022Enrolled35ConditionsBipolar DepressionArmsAllogenic FMT, Autologous FMT
3 · Its place in the literature

Who cites it

282 citing papers in PubMed, 5 syntheses or guidelines pooled it, 583 citations in OpenAlex.

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222 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Anastasia I PetraMolecular Immunopharmacology and Drug Discovery Laboratory, Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, Massachusetts.
Smaro PanagiotidouMolecular Immunopharmacology and Drug Discovery Laboratory, Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, Massachusetts.
Erifili HatziagelakiSecond Department of Internal Medicine, Attikon General Hospital, Athens Medical School, Athens, Greece.
Julia M StewartMolecular Immunopharmacology and Drug Discovery Laboratory, Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, Massachusetts.
Pio ContiDepartment of Medical Sciences, Immunology Division, University of Chieti, Via dei Vestini, Chieti, Italy.
Theoharis C TheoharidesMolecular Immunopharmacology and Drug Discovery Laboratory, Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, Massachusetts; Department of Internal Medicine, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts; Department of Psychiatry, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts. Electronic address: theoharis.theoharides@tufts.edu.
Tufts University · USUniversity General Hospital Attikon · GRUniversity of Chieti-Pescara · IT

Funding

Stress Induces Skin Mast Cell Activation &VasodilationR01AR047652 · NIAMS · TUFTS UNIVERSITY BOSTON · PI THEOHARIDES, THEOHARIS C. · 2001 to 2011
$3.0M
CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL AR01NS038326 · NINDS · TUFTS UNIVERSITY BOSTON · PI THEOHARIDES, THEOHARIS C · 1999 to 2001
$511k
NIAMS NIH HHS AR47652NIAMS NIH HHS R01 AR047652NINDS NIH HHS NS38326NINDS NIH HHS R01 NS038326
6 · The paper itself

Abstract

purposeGut microbiota regulate intestinal function and health. However, mounting evidence indicates that they can also influence the immune and nervous systems and vice versa. This article reviews the bidirectional relationship between the gut microbiota and the brain, termed the microbiota-gut-brain (MGB) axis, and discusses how it contributes to the pathogenesis of certain disorders that may involve brain inflammation.

methodsArticles were identified with a search of Medline (starting in 1980) by using the key words anxiety, attention-deficit hypersensitivity disorder (ADHD), autism, cytokines, depression, gut, hypothalamic-pituitary-adrenal (HPA) axis, inflammation, immune system, microbiota, nervous system, neurologic, neurotransmitters, neuroimmune conditions, psychiatric, and stress.

findingsVarious afferent or efferent pathways are involved in the MGB axis. Antibiotics, environmental and infectious agents, intestinal neurotransmitters/neuromodulators, sensory vagal fibers, cytokines, and essential metabolites all convey information to the central nervous system about the intestinal state. Conversely, the hypothalamic-pituitary-adrenal axis, the central nervous system regulatory areas of satiety, and neuropeptides released from sensory nerve fibers affect the gut microbiota composition directly or through nutrient availability. Such interactions seem to influence the pathogenesis of a number of disorders in which inflammation is implicated, such as mood disorder, autism-spectrum disorders, attention-deficit hypersensitivity disorder, multiple sclerosis, and obesity. IMPLICATIONS: Recognition of the relationship between the MGB axis and the neuroimmune systems provides a novel approach for better understanding and management of these disorders. Appropriate preventive measures early in life or corrective measures such as use of psychobiotics, fecal microbiota transplantation, and flavonoids are discussed.

Indexed as

AnxietyAttention Deficit Disorder with HyperactivityBrainCytokinesDepressionGastrointestinal MicrobiomeHumansHypothalamo-Hypophyseal SystemMultiple SclerosisNervous System DiseasesNeuroimmunomodulationPituitary-Adrenal SystemCytokinescytokinesgutimmune disordersMGB axismicrobiotanervous system diseases

Identifiers

PMID26046241
PMCPMC4458706
OpenAlexW1603039868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.