Evidence map›Paper›PMID 26046103›Full record

ArticleJournal of dentistry (Shiraz, Iran)2015

Evaluation of Minichromosome Maintenance-3 (MCM3) in Oral Squamous Cell Carcinoma.

Gita Rezvani, Azadeh Andisheh-Tadbir, Mohammad Javad Ashraf, Sara Amanpour, Fereshteh Kamali, Sorena Fardisi

Open access · greenAbstract read

In one paragraph

Article in Journal of dentistry (Shiraz, Iran), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it

0cells of the map it votes in

10citing papers in PubMed

1.5field-weighted citation impact, top 18% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

The role of cell cycle-related genes in the tumorigenesis of adrenal and thyroid neuroendocrine tumors.Heliyon · 2025
Review
Expression analysis of cyclin D, Ki-67, MCM3 and MCM2 in oral squamous cell carcinoma.Bioinformation · 2023
Article
Association of High Immunohistochemical Expression of Minichromosome Maintenance 3 with Human Oral Squamous Cell Carcinoma-A Preliminary Study.Diagnostics (Basel, Switzerland) · 2022
Article
SWATH-MS Based Proteomic Profiling of Prostate Cancer Cells Reveals Adaptive Molecular Mechanisms in Response to Anti-Androgen Therapy.Cancers · 2021
Article
The antitumour effect of galangin and luteolin with doxorubicin on chemically induced hepatocellular carcinoma in rats.Contemporary oncology (Poznan, Poland) · 2021
Article
PLK1 promotes proliferation and suppresses apoptosis of renal cell carcinoma cells by phosphorylating MCM3.Cancer gene therapy · 2020
Article
[Deguelin inhibits proliferation and regulates the expression of MCM3-CDC45 in MCF-7 and H1299 cells in vitro].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017
Article
Upregulation of minichromosome maintenance complex component 3 during epithelial-to-mesenchymal transition in human prostate cancer.Oncotarget · 2017
Article
MCM7 expression is correlated with histological subtypes of lung adenocarcinoma and predictive of poor prognosis.International journal of clinical and experimental pathology · 2017
Article
Minichromosome maintenance protein 5 - a promising prognostic marker of oral epithelial dysplasias and oral squamous cell carcinomas.Journal of oral and maxillofacial pathology : JOMFP
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Gita RezvaniDept. of Oral & Maxillofacial Pathology, Dental School of Shahed University, Tehran, Iran;

Azadeh Andisheh-TadbirDept. of Oral & Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran;

Mohammad Javad AshrafDept. of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;

Sara AmanpourDept. of Oral & Maxillofacial Pathology, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran;

Fereshteh KamaliPost Graduate Student, Dept. of Oral & Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran;

Sorena FardisiPost Graduate Student, Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran;

Shiraz University of Medical Sciences · IRKerman University of Medical Sciences · IRShahed University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

statement of the problemThe expression of minichromosome maintenance-3 (MCM3) proteins and their diagnostic value in oral mucosal dysplasia and squamous cell carcinoma (SCC) is not well known. PURPOSE: This study was conducted to evaluate the usefulness of minichromosome maintenance 3 (MCM3) as a biomarker for diagnosis of oral premalignant lesions and SCC. MATERIALS AND

methodIn this study, 31 oral SCC, 20 dysplastic epithelium and 20 controls were selected and immunohistochemical staining was done for MCM3. ANOVA, Tukey HSD, Mann-Whitney and Kruskal-Wallis tests were used to compare the groups and the correlation between different grades.

resultsThere was increasing trend of MCM3 from control to dysplastic epithelium and from dysplastic epithelium to SCC both in suprabasal layers and in total epithelial layers. MCM3 expression was elevated with increasing the grade of dysplasia, but there was no statistically significant difference (p= 0.93). The expression was also increased in high grades of SCC compared to lower grades.

conclusionMCM3 can be used as a useful biomarker in the diagnosis of premalignant lesions and oral SCC.

Indexed as

CarcinomaMCM3Oral Epithelial DysplasiaOral Squamous Cell

Identifiers

PMID26046103

PMCPMC4445857

OpenAlexW2156081623

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.