Evidence map›Paper›PMID 26046022›Full record

ArticleJournal of the West African College of Surgeons

Prevalence of abnormal bone mineral density in hiv-positive patients in ibadan, Nigeria.

T O Alonge, V N Okoje-Adesomoju, O M Atalabi, H A Obamuyide, D Olaleye, I F Adewole

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In one paragraph

Article in Journal of the West African College of Surgeons. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Osteoporosis in Africa-where are we now.Clinical rheumatology · 2021
    Review
  2. Article
  3. Physical activity levels among Malawian adults living with HIV and receiving anti-retroviral therapy.Malawi medical journal : the journal of Medical Association of Malawi · 2020
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

T O AlongeDepartment of Surgery, University of Ibadan and University College Hospital, Ibadan, Nigeria.
V N Okoje-AdesomojuDepartment of Oral and Maxillofacial Surgery, University of Ibadan and University College Hospital, Ibadan. vnokoje@gmail.com.
O M AtalabiDepartment of Radiology, University of Ibadan and University College Hospital, Ibadan. omatalabi@yahoo.co.uk.
H A ObamuyideDepartment of Orthopaedics and Trauma, University College Hospital, Ibadan. henry.obamuyide@gmail.com.
D OlaleyeDepartment of Virology, University of Ibadan, Ibadan. davidoolaleye@gmail.com.
I F AdewoleDepartment of Obstetrics and Gynaecology, University of Ibadan and University College Hospital, Ibadan. ifadewole@yahoo.co.uk.
University of Ibadan · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere have been reports of high rate of abnormal bone mineral densities (BMD) among people living with HIV. Following the introduction of combination antiretroviral therapy (CART) into Nigeria, the country is now home to increasing population of HIV positive patients. There is paucity of data about osteoporosis/osteopaenia and bone mineral density in this population. AIM AND

objectivesThe aim of the study was to determine the prevalence and determinants of osteopaenia/osteoporosis in a cohort of HIV-positive patients in Nigeria. PATIENTS AND

methodsThe BMD of a group of patients attending the outpatient clinic of the University of Ibadan, Nigeria was assessed using a DXA machine. The relationship of bone mineral density to body weight, CART status, protease inhibitor use, and gender was investigated. Their CD4 counts and viral load were also estimated.

resultsA total of 1005 patients participated with a mean age of 41.3 ± 10 years. There were 724 females (72.0%) and 29.7% were single. The median length of diagnosis was 2 years (Range 1-18 years). The Median CD4 count was 371cells/ml and Median viral load was 200 copies/ml. Of this sample, 785 (78.1%) were on CART with 99 (12.6%) on protease inhibitor. The mean body mass index (BMI) was 23.7±4.7 with 9.2% underweight and 10% obese. The prevalence of osteopaenia and osteoporosis were 46.6% and 31.9% respectively, while 19.6% had normal bone mineral density (BMD). Osteoporosis was significantly higher in those aged above 40 years (p= 0.00001), the females (p= 0.022), the single (p=0.028) and the underweight (p=0.0001). There was no significant difference in BMD of those with or without protease inhibitor containing medications as well as treatment naïve patients.

conclusionA high prevalence of abnormal bone mineral density was found in HIV positive patients in Nigeria. Patient age above 40 years and a body mass index class of underweight were significant associated factors. Routine bone mineral density assessment is recommended as an adjunct in the evaluation of HIV positive patients in Nigeria.

Indexed as

Bone mineral densityCombination-antiretroviral-therapyHIV/AIDSNigeriaOsteopaeniaOsteoporosisPrevalence

Identifiers

PMID26046022
PMCPMC4437238
OpenAlexW2416837355

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.