ArticleAmerican journal of cancer research2015
Increased expression of iASPP correlates with poor prognosis in FIGO IA2-IIA cervical adenocarcinoma following a curative resection.
Article in American journal of cancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 10 citations in OpenAlex.
- Differential Expression of Apoptosis-Stimulating Proteins of p53 (ASPPs) Between Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma.Diagnostics (Basel, Switzerland) · 2026Article
- PPP1R13L drives cervical cancer progression by suppressing p63-mediated PTEN transcription.Cellular and molecular life sciences : CMLS · 2025Article
- Elevated Expression of Inhibitor of Apoptosis-stimulating Protein of p53 (iASPP) and Methyltransferase-like 3 (METTL3) Correlate with Poor Prognosis in FIGO Ib1-IIa Squamous Cell Cervical Cancer.Journal of Cancer · 2020Article
- LncRNA XIST Promotes Growth of Human Chordoma Cells by Regulating miR-124-3p/iASPP Pathway.OncoTargets and therapy · 2020Article
- Mild Therapeutic Hypothermia Protects the Brain from Ischemia/Reperfusion Injury through Upregulation of iASPP.Aging and disease · 2018Article
- The family of apoptosis-stimulating proteins of p53 is dysregulated in colorectal cancer patients.Oncology letters · 2018Article
- 2-anilino-4-amino-5-aroylthiazole-type compound AS7128 inhibits lung cancer growth through decreased iASPP and p53 interaction.Cancer science · 2018Article
- iASPP facilitates tumor growth by promoting mTOR-dependent autophagy in human non-small-cell lung cancer.Cell death & disease · 2017Article
- iASPP overexpression is associated with clinical outcome in spinal chordoma and influences cellular proliferation, invasion, and sensitivity to cisplatinOncotarget · 2017Article
- Overexpressed LAPTM4B-35 is a risk factor for cancer recurrence and poor prognosis in non-small-cell lung cancer.Oncotarget · 2016Article
- Surgery combined with chemotherapy for recurrent gastric cancer achieves better long-term prognosis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe function of iASPP (inhibitory member of the ASPP family) in cervical adenocarcinoma remains unknown. The aim of this study was to explore the expression and clinical relevance of iASPP in early stage cervical adenocarcinoma. Methods The clinical data of 75 patients with FIGO stage IA2-IIA cervical adenocarcinoma who were treated with radical hysterectomy from January 2004 to March 2008 was collected. The mRNA and protein expression levels of iASPP from the paired tumor specimens and adjacent normal cervical tissues were determined by real-time qRT-PCR and Western blot, and its relationship with clinicopathologic factors and prognosis of cervical cancer patients was retrospectively analyzed.
resultsThe mRNA and protein expression levels of iASPP were significantly elevated in cervical cancer tissues. The increased iASPP expression was correlated strongly with higher FIGO staging (p = 0.034), worse differentiation (p = 0.046), less pelvic lymph node metastasis (p = 0.014), and poor overall and disease-free survival of patients with cervical cancer (both P > 0.05). Multivariate Cox analysis indicated that high iASPP expression was an independent prognostic factor (P > 0.05).
conclusionsThis study demonstrates that iASPP is highly elevated in cervical adenocarcinoma, and that overexpression is an independent poor prognostic indicator for early stage cervical cancer patients, suggesting that iASPP might serve as a novel potential prognostic marker and therapeutic target for cervical adenocarcinoma.
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