Evidence map›Paper›PMID 26045901›Full record

ArticleAmerican journal of translational research2015

Internal relationship between symptomatic venous thromboembolism and risk factors: up-regulation of integrin β1, β2 and β3 levels.

Qianglin Duan, Lemin Wang, Fan Yang, Jue Li, Yanli Song, Zhu Gong, Guiyuan Li, Haoming Song, Xiaoyu Zhang, Zugang Shen and 1 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Qianglin DuanDepartment of Cardiology, Tongji Hospital, Tongji University Shanghai, China.
Lemin WangDepartment of Cardiology, Tongji Hospital, Tongji University Shanghai, China.
Fan YangDepartment of Experimental Diagnosis, Tongji Hospital, Tongji University Shanghai, China.
Jue LiDepartment of Medical Statistics, School of Medicine, Tongji University Shanghai, China.
Yanli SongDepartment of Internal Emergency, Tongji Hospital, Tongji University Shanghai, China.
Zhu GongDepartment of Cardiology, Tongji Hospital, Tongji University Shanghai, China.
Guiyuan LiDepartment of Oncology, Tongji Hospital, Tongji University Shanghai, China.
Haoming SongDepartment of Cardiology, Tongji Hospital, Tongji University Shanghai, China.
Xiaoyu ZhangDepartment of Rheumatology, Tongji Hospital, Tongji University Shanghai, China.
Zugang ShenDepartment of Surgical Emergency, Tongji Hospital, Tongji University Shanghai, China.
Anthony DartDepartment of Cardiovascular Medicine, Alfred Hospital, Monash University Melbourne, Australia.
Tongji University · CNTongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo compare different expression of core proteins among venous thromboembolism (VTE) and those with risk factor groups and analyze the relative risk for VTE after integrating integrin β1, β2 and β3 expression.

methodsA total of 1006 subjects were recruited and divided into VTE group, risk factor groups and control (non- risk factor) group. Flow cytometry was performed to detect the expression of integrin β1, β2 and β3. The relative risk for VTE was evaluated with independent, parallel and serial methods.

resultsThe expression of integrin β1 increased markedly in VTE patients, and those with risk factors (acute infection, malignancy, and autoimmune diseases), respectively (P < 0.001 or 0.01). The expression of integrin β1 in trauma/surgery group was not significantly different with control group (P > 0.05). The expression of integrin β2 or β3 significantly increased in VTE group, but that in risk factor groups was not significantly increased (P > 0.05). Multivariate analysis revealed the trauma/surgery groups had no significantly increased risk for VTE.

conclusionsVTE group patients have significantly increased expression of integrin β1, β2 and β3, and risk factor groups (acute infection, malignancy and autoimmune disease) have significantly increased expression of integrin β1. The significant increase in integrin β2, β3 expression is a marker differentiating of VTE group patients with other risk factor groups. Trauma/surgery group has no increased expression of integrin β1, β2 and β3 as other risk factors. Thus, that trauma/surgery may be not the "true" risk factor for VTE.

Indexed as

integrin β1risk factorVenous thromboembolismβ2 and β3

Identifiers

PMID26045901
PMCPMC4448201
OpenAlexW2295628420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.