ArticleAmerican journal of translational research2015
A novel injectable porous surface modified bioactive bone cement for vertebroplasty: an in vivo biomechanical and osteogenic study in a rabbit osteoporosis model.
Article in American journal of translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- Advances in materials used for minimally invasive treatment of vertebral compression fractures.Frontiers in bioengineering and biotechnology · 2023Review
- Bone microarchitectural parameters can detect oxytocin induced changes prior to bone density on mitigating bone deterioration in rabbit osteoporosis model using micro-CT.BMC musculoskeletal disorders · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
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Abstract
purposeThe aim of this study is to determine the feasibility and effectiveness of a novel injectable Porous Surface Modified Bioactive Bone Cement (PSMBBC) for vertebroplasty of aiding osteoporotic vertebrae in an osteoporosis model.
methods72 osteoporosis rabbits were randomly divided into three groups: the Polymethyl Methacrylate (PMMA) group, the PSMBBC group and the control group. PMMA and PSMBBC were administrated to osteoporotic vertebrae in vertebroplasty, respectively. The animals were sacrificed at 1w, 4w, 12w after the procedure. Micro-CT analysis, biomechanical tests and histological analysis were performed at each time point.
resultsFrom 4 to 12 weeks after the implantation of bone cements, the bone volume fraction (BV/TV) of the PSMBBC group increased from 28.27 ± 1.69% to 38.43 ± 1.34%. However, the BV/TV of the PMMA group showed no significant difference after the implantation. At 4 weeks, direct contact between the bone and the bone cement was observed in the PSMBBC group. At 12 weeks, it was discovered that new intact bone trabecular was formed in PSMBBC group. Furthermore, the maximum compressive strength values of the PSMBBC group were significantly higher than those of the control group at each time point after implantation.
conclusionsIn summary, this study was the first investigation to evaluate the potential application of PSMBBC for vertebroplasty. RESULTS demonstrated its beneficial effects on the trabecular ingrowth of new bone and bone mineral density increase. With further validation, PSMBBC can become a valuable biomaterial for aiding osteoporotic vertebrae and usable bone cement applied in vertebroplasty.
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26045894PMC4448194W2415019675What OpenQuestion holds
Registered trials
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