Evidence map›Paper›PMID 26045839›Full record

ArticleInternational journal of clinical and experimental pathology2015

Association between ERCC5 gene polymorphisms and breast cancer risk.

Nari Na, Eer Dun, Lidong Ren, Guoxin Li

Open access · greenAbstract read
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Genetic polymorphism inMolecular biology research communications · 2019
    Article
  7. Article
  8. International journal of molecular epidemiology and genetics · 2018
    Article
  9. High expression of ERCC5 predicts a poor prognosis in hepatocellular carcinoma.International journal of clinical and experimental pathology · 2018
    Article
  10. Article
  11. Oncotarget · 2017
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nari NaDepartment of General Surgery, Nanfang Hospital, Southern Medical University Guangzhou, China ; Department of Thyroid, Breast, Hernia and Vascular Surgery, Inner Mongolia People's Hospital Hohhot, China.
Eer DunDepartment of Respiratory, Inner Mongolia People's Hospital Hohhot, China.
Lidong RenDepartment of Thyroid, Breast, Hernia and Vascular Surgery, Inner Mongolia People's Hospital Hohhot, China.
Guoxin LiDepartment of General Surgery, Nanfang Hospital, Southern Medical University Guangzhou, China.
Inner Mongolia People's Hospital · CNNanfang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a case-control study to evaluate the association between ERCC5 polymorphism and breast cancer risk. 325 breast cancer patients and 325 controls were recruited in our study between January 2011 and March 2014. ERCC5 rs1047768, rs2094258, rs2296147, rs751402 and rs873601 polymorphisms were genotyped, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. By logistic regression analysis, we found that individuals with AA genotype of rs2094258 was associated with increased risk of breast cancer when compared with wide-type genotype, and the OR (95% CI) was 1.80 (1.12-2.92) for AA genotype. Individuals with GA+GG genotype of rs2094258 were significantly correlated with increased risk of breast cancer in tobacco smokers, and the OR (95% CI) was 7.35 (1.21-47.20). In conclusion, our study indicated that ERCC5 rs2094258 polymorphism may contribute to the risk of breast cancer.

Indexed as

AdultAgedBreast NeoplasmsCase-Control StudiesDNA-Binding ProteinsDNA Excision Repair Protein ERCC-5EndonucleasesFemaleGenetic Predisposition to DiseaseGenotypeHumansMiddle AgedNuclear ProteinsPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotideDNA-Binding ProteinsDNA Excision Repair Protein ERCC-5EndonucleasesNuclear ProteinsTranscription Factorsbreast cancerERCC5polymorphism

Identifiers

PMID26045839
PMCPMC4440148
OpenAlexW2414761404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.