ArticleInternational journal of clinical and experimental pathology2015
TNF-α-308G/A polymorphism associated with TNF-α protein expression in patients with diabetic nephropathy.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Deciphering the Role of Sirtuin-1 Gene Polymorphism in Diabetic Nephropathy: A Systematic Review and Meta-Analysis.Journal of diabetes research · 2026Pooled it
- Pooled it
- Review of Genetic Variation as a Predictive Biomarker for Chronic Graft-Versus-Host-Disease After Allogeneic Stem Cell Transplantation.Frontiers in immunology · 2020Pooled it
- Frequency of Tumor Necrosis Factor-α, Interleukin-6, and Interleukin-10 Gene Polymorphisms in Mexican Patients with Diabetic Retinopathy and Diabetic Kidney Disease.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Comparative analysis of TNF-α (-308) gene polymorphism in Turkish patients with type 2 diabetes developing nephropathy and/or neuropathy.Scientific reports · 2024Article
- Article
- Association of TNF-α-308 G>A (rs1800629) polymorphism with susceptibility of metabolic syndrome.Journal of diabetes and metabolic disorders · 2021Article
- Serum profile of cytokines and their genetic variants in metabolic syndrome and healthy subjects: a comparative study.Bioscience reports · 2019Article
- Rhein lysinate protects renal function in diabetic nephropathy of KK/HlJ mice.Experimental and therapeutic medicine · 2017Article
- TNF-α and IL10 polymorphisms interaction increases the risk of ankylosing spondylitis in Chinese Han population.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis study was to clarify the regulated effects of TNF-α -308G/A polymorphism on TNF-α and investigate the relationship of -308G/A polymorphisms with diabetic nephropathy (DN) susceptibility.
methods86 DN patients and 94 healthy individuals were enrolled in our study. Polymerase chain reaction-sequence specific primer (PCR-SSP) detection technology was used to testify single nucleotide polymorphism (SNP) of TNF-α gene. Enzyme-linked immunosorbent assay (ELISA) was used to measure the content of TNF-α protein. Odds ratio (OR) with 95% CI were used to evaluate the association of TNF-α -308G/A polymorphism and DN susceptibility.
resultsThe level of TNF-α protein was much higher in DN patients compared to that of controls (P<0.05). For TNF-α -308G/A, G/A genotype could increase the risk for DN (OR=2.15, 95% CI=1.08-4.30). Moreover, a allele frequency was found higher in cases compared with controls, which suggested that A allele served as an genetic-susceptibility factor for DN (OR=1.89, 95% CI=1.10-3.26). Further analysis indicated that level of TNF-α for individuals with mutant genotype (GA and AA) were higher than that of individuals with wild genotype (P<0.05). However, AA genotype showed no effects on DN susceptibility (OR=2.08, 95% CI=0.56-7.33).
conclusionTNF-α-308G/A polymorphism was associated with expression level of TNF-α and served as an genetic-susceptibility factor for DN.
Indexed as
Identifiers
26045828PMC4440137W1159818036What OpenQuestion holds
Registered trials
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