ArticleInternational journal of clinical and experimental pathology2015
Two SNPs of ATP-binding cassette B1 gene on the risk and prognosis of colorectal cancer.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Association between ABCB1 (3435C>T) polymorphism and susceptibility of colorectal cancer: A meta-analysis.Medicine · 2020Pooled it
- A meta-analysis ofThe Journal of international medical research · 2019Pooled it
- Association between MDR1 C3435T polymorphism and colorectal cancer risk: A meta-analysis.Medicine · 2017Pooled it
- Association betweenOncology letters · 2020Article
- The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer.Archives of medical science : AMS · 2020Article
- Article
- Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, anFrontiers in oncology · 2019Article
- Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells.Cancer letters · 2019Article
- Haplotype Analysis of MDR1 and Risk for Cervical Cancer in Northeastern ThailandAsian Pacific journal of cancer prevention : APJCP · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a case-control study to investigate the role of ABCB1 C3435T and G2677T/A in the susceptibility and prognosis of colorectal cancer patients. A total of 316 patients with colorectal cancer and 316 controls were collected between January 2009 and January 2011. Genotyping of ABCB1 C3435T and G2677T/A was conducted by the methods of Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Conditional logistic regression analysis showed that subjects carrying CT and CC genotypes of ABCB1 C3435T were more frequently observed in colorectal cancer patients when compared with controls, and the adjusted ORs were 1.62 (1.05-2.52) and 2.05 (1.25-3.36), respectively. By Cox regression analysis, we found that the TT genotype of ABCB1 C3435T was significantly associated with shorter PFS and OS in patients with colorectal cancer when compared with CC genotype, with adjusted HR (95% CI) of 2.57 (1.14-6.04) and 2.54 (1.05-6.61), respectively. We found that the ABCB1 C3435T polymorphism could affect the susceptibility and clinical outcome of colorectal cancer patients.
Indexed as
Identifiers
26045821PMC4440130W2410993569What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.