ArticleInternational journal of clinical and experimental pathology2015
Association between KIAA1199 overexpression and tumor invasion, TNM stage, and poor prognosis in colorectal cancer.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- KIAA1199 (CEMIP) regulates adipogenesis and whole-body energy metabolism.Bone research · 2025Article
- Comprehensive identification of hub mRNAs and lncRNAs in colorectal cancer using galaxy: an in silico transcriptome analysis.Discover oncology · 2025Article
- Distinct chemical structures inhibit the CEMIP hyaluronidase and promote oligodendrocyte progenitor cell maturation.The Journal of biological chemistry · 2024Article
- The role of CEMIP in cancers and its transcriptional and post-transcriptional regulation.PeerJ · 2024Review
- RAD21 is the core subunit of the cohesin complex involved in directing genome organization.Genome biology · 2023Article
- HIF1α/CCL7/KIAA1199 axis mediates hypoxia-induced gastric cancer aggravation and glycolysis alteration.Journal of clinical biochemistry and nutrition · 2023Article
- Downregulation of KIAA1199 alleviated the activation, proliferation, and migration of hepatic stellate cells by the inhibition of epithelial-mesenchymal transition.Open medicine (Warsaw, Poland) · 2023Article
- CEMIP, a Promising Biomarker That Promotes the Progression and Metastasis of Colorectal and Other Types of Cancer.Cancers · 2022Review
- lncRNA NEAT1 Promotes Colorectal Cancer Progression by Increasing Inflammation.Journal of oncology · 2022Article
- Study of the effect of pain on postoperative rehabilitation of patients with uterine malignant tumor.Frontiers in surgery · 2022Article
- Potential functional variants of KIAA genes are associated with breast cancer risk in a case control study.Annals of translational medicine · 2021Article
- Overexpression of KIAA1199 is an independent prognostic marker in laryngeal squamous cell carcinoma.PeerJ · 2020Article
- Article
- KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway.Oncogene · 2019Article
- CircRNA hsa_circ_0004585 as a potential biomarker for colorectal cancer.Cancer management and research · 2019Article
- KIAA1199 promotes invasion and migration in non-small-cell lung cancer (NSCLC) via PI3K-Akt mediated EMT.Journal of molecular medicine (Berlin, Germany) · 2019Article
- An Integrated Approach for Identifying Molecular Subtypes in Human Colon Cancer Using Gene Expression Data.Genes · 2018Article
- KIAA1199 is induced by inflammation and enhances malignant phenotype in pancreatic cancer.Oncotarget · 2017Article
- Article
- Central Role of CEMIP in Tumorigenesis and Its Potential as Therapeutic Target.Journal of Cancer · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the expression of KIAA1199 in tumor tissue and its potential value as a prognostic indicator of survival in patients with colorectal cancer (CRC). The expression of KIAA1199 mRNA in CRC was characterized using real-time PCR and 20 pairs of fresh-frozen CRC tissues and corresponding non-cancerous tissues. KIAA1199 protein expression was confirmed using immunohistochemistry on a tissue microarray chip from 202 patients with CRC. Then, we correlated KIAA1199 protein expression to CRC conventional clinicopathological features and patient's outcome. The expression of KIAA1199 mRNA and protein were up-regulated in CRC compared to normal tissues (P=0.015 and P<0.001, individually). KIAA1199 protein expression was related to tumor invasion depth (P=0.013) and lymph node metastasis (P=0.003). Kaplan-Meier survival and Cox regression analyses revealed that high KIAA1199 expression (P<0.001) and serum carcinoembryonic antigen (CEA) level post operation (P=0.005) were independent factors predicting poor prognosis of patients with CRC. We present evidence that high expression of KIAA1199 is associated with tumor invasion depth, TNM stage, and poor prognosis in CRC. Our findings suggest KIAA1199 could be used as a prognostic factor and novel therapeutic target for CRC.
Indexed as
Identifiers
26045799PMC4440108W654492798What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.