Evidence map›Paper›PMID 26045794›Full record

ArticleInternational journal of clinical and experimental pathology2015

Identification of functional tag single nucleotide polmorphisms within the entire CAT gene and their clinical relevance in patients with noise-induced hearing loss.

Junhui Yang, Jieyuan Zhang, Xiaoming Wang, Chaoyong Wang, Jichuan Chen, Yu Qian, Zhaoxia Duan

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In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Integrating pharmacogenomics into clinical trials of hearing disorders.The Journal of the Acoustical Society of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Junhui YangDepartment of Otolaryngology Head and Neck Surgery, Daping Hospital, Third Military Medical University Chongqing 400042, China.
Jieyuan ZhangDepartment 6 of Research Institute of Surgery, Daping Hospital, Third Military Medical University, State Key Laboratory of Trauma, Burns and Combined Injury Chongqing 400042, China.
Xiaoming WangPrevention and Control Center of Disease of Chongqing Fuling Chongqing 408000, China.
Chaoyong WangChongqing Fuling Central Hospital Chongqing 408000, China.
Jichuan ChenDepartment of Otolaryngology Head and Neck Surgery, Daping Hospital, Third Military Medical University Chongqing 400042, China.
Yu QianDepartment of Otolaryngology Head and Neck Surgery, Daping Hospital, Third Military Medical University Chongqing 400042, China.
Zhaoxia DuanDepartment 6 of Research Institute of Surgery, Daping Hospital, Third Military Medical University, State Key Laboratory of Trauma, Burns and Combined Injury Chongqing 400042, China.
Army Medical University · CNFuling Center Hospital of Chongqing · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesNoise-induced hearing loss (NIHL) is an important occupational disease which results from an interaction between genetic and environmental factors. More and more evidences suggested that Catalase (CAT) gene polymorphism plays an important role in the development of NIHL. The aim of this study was to investigate the association of CAT gene polymorphisms with NIHL in a case-control study.

designA total of 719 unrelated adult Chinese Han population, including 225 healthy volunteers and 494 noise-exposed workers were recruited in this study. Six tag single-nucleotide polymorphisms (tSNPs) were genotyped using an improved multiplex ligation detection reaction technique. Subsequently, the interaction between noise exposure level and genotypes and their effect on NIHL were analyzed using logistic regression.

resultsAmong six tSNPs, two of them (rs208679 and rs769217) were significantly associated with noise exposure level. For rs208679 recessive effect, GG genotype had a significantly increased of NIHL risk in the exposure level of <85 dB; and for rs769217 dominant effect, the combined genotypes TT/TC had a significantly increased of NIHL risk in the exposure level of 85 dB~92 dB; and the haplotype A-G-T-C-A-C had a risk effect on the NIHL in the exposure level of 85 dB~92 dB. In addition, the rs769217 polymorphism could enhance the transcription activities of the CAT gene.

conclusionsThis study identified CAT is a NIHL susceptibility gene when noise exposure levels are taken into account. Rs208679 and rs769217 polymorphisms might be used as relevant risk estimates for the development of NIHL in population with different noise exposure levels.

Indexed as

AdolescentAdultAsian PeopleAudiometry, Pure-ToneCase-Control StudiesCatalaseEnzyme-Linked Immunosorbent AssayFemaleGenetic Predisposition to DiseaseGenotypeHearing Loss, Noise-InducedHumansMaleMiddle AgedOccupational DiseasesPolymorphism, Single NucleotideCatalaseCAT protein, humancatalaseclinical relevanceNoise-induced hearing losssingle-nucleotide polymorphismtag

Identifiers

PMID26045794
PMCPMC4440103
OpenAlexW979498161

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.