ArticleInternational journal of clinical and experimental pathology2015
FoxM1 influences mouse hepatocellular carcinoma metastasis in vitro.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Exogenous delivery of microRNA-134 (miR-134) using α-tocopherol-based PEGylated liposome for effective treatment in skin squamous cell carcinoma.Drug delivery and translational research · 2021Article
- Quantitative Expression of Key Cancer Markers in the AS-30D Hepatocarcinoma Model.Frontiers in oncology · 2021Article
- MiRNA-134 suppresses esophageal squamous cell carcinoma progression by targeting FOXM1.International journal of clinical and experimental pathology · 2019Article
- Basic Transcription Factor 3 Is Required for Proliferation and Epithelial-Mesenchymal Transition via Regulation of FOXM1 and JAK2/STAT3 Signaling in Gastric Cancer.Oncology research · 2017Article
- Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1.Oncology reports · 2017Article
- Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1.Oncology reports · 2017Article
- Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation.Oncotarget · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymph node metastasis is recognized as an important mode of liver cancer metastasis. Two hepatocarcinoma cell lines, Hca-F get high (75%) and Hca-P get low (25%) incidences of lymph node metastasis. Forkhead box M1 (FoxM1) is described as a major oncogenic transcription factor in tumor initiation, promotion, and progression. Ezrin is linked to aggressive tumor behavior by involving all stages of tumor metastasis. We firstly compared the expression of FoxM1 and Ezrin between two cells. Then we transiently transfected Hca-P cells with over-FoxM1 plasmid and Hca-F cells with sh-FoxM1 plasmid. We found that both FoxM1 and Ezrin expressed higher in Hca-F than Hca-P. We successfully down-regulated or up-regulated FoxM1 expression in Hca-F or Hca-P cells. And we found that FoxM1 had correlation with proliferation, invasion and migration in mouse hepatocellular carcinoma cell lines.
Indexed as
Identifiers
26045783PMC4440092W2409286267What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.