Immunity of fungal infections alleviated graft reject in liver transplantation compared with non-fungus recipients.

Tonghai Xing, Lin Zhong, Lihui Lin, Guoqiang Qiu, Zhihai Peng

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Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

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5 authors at 2 institutions in 1 country.

Tonghai XingDepartment of General Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai 200080, China.

Lin ZhongDepartment of General Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai 200080, China.

Lihui LinDepartment of Laboratory Medicine, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai 200080, China.

Guoqiang QiuDepartment of General Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai 200080, China.

Zhihai PengDepartment of General Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai 200080, China.

Shanghai First People's Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate of the immune tolerance in adult LT recipients with Invasive fungal infections (IFIs).

methods109 consecutive LT recipients who received LT were included. Percentage of T subsets (CD4+CD25hiCD127- T cells, CD4+CD25loCD45RA+ T cells, CD4+CD25loCD45RA- and CD4+CD45RA-CD45RO+ T cells populations), levels of cytokines (IL-1b, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ, IL-12p70, IL-17, TNF-α, TNF-β and GM-CSF) were detected by FACS and Bioplex in peripheral blood. Biopsy specimens were fixed, monoclonal antibodies against CD4, Foxp3 and IL-17 were applied to the above sections and FISH was performed.

resultsThe risk of acute rejection was decreased in fungal infected liver transplant recipients comparing with non-fungal infected group. CD4+CD25hiCD127T cell population was increased in peripheral blood and memory CD4+CD45RA-CD45RO+ T cell population decreased. There was significant lower levels observed in naïve CD4+CD25loCD45RA+ and CD4+CD25loCD45RA- T cell populations in fungal infected liver transplant. Moreover, IL-2, IL-6, IL-10 and GM-CSF were decreased. However, no significant difference with IL-4 and IL-8 in serum in two infected LT recipients.

conclusionThe incidence of graft rejection in liver transplantation recipients with fungal infections was lower than the non-fungal group. It is important to assess the risk during pretransplant and postoperation for liver transplantation.

Indexed as

AdultCytokinesFemaleFlow CytometryGraft RejectionHumansImmunocompromised HostImmunohistochemistryIn Situ Hybridization, FluorescenceLiver TransplantationMaleMiddle AgedMycosesRetrospective StudiesT-Lymphocyte SubsetsCytokinescytokinesfungal infectionsGraft rejectionliver transplantationT cell subsets

Identifiers

PMID26045766

PMCPMC4440075

OpenAlexW2406316869

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.