Evidence map›Paper›PMID 26045727›Full record

ArticleBiomicrofluidics2015

Impact of microfluidic processing on bacterial ribonucleic acid expression.

Senthil Kumar Gandi, David Watson, Maïwenn Kersaudy-Kerhoas, Marc P Y Desmulliez, Till Bachmann, Helen Bridle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomicrofluidics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Senthil Kumar GandiDivision of Infection and Pathway Medicine, University of Edinburgh , Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom.
David Watson
Maïwenn Kersaudy-KerhoasInstitute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University , Edinburgh EH14 4AS, United Kingdom.
Marc P Y DesmulliezInstitute of Sensors, Signals and Systems, Heriot-Watt University , Edinburgh EH14 4AS, United Kingdom.ORCID 0000-0002-2441-1598
Till BachmannDivision of Infection and Pathway Medicine, University of Edinburgh , Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom.
Helen BridleInstitute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University , Edinburgh EH14 4AS, United Kingdom.

Funding

Medical Research Council MC_PC_12014
6 · The paper itself

Abstract

Bacterial transcriptomics is widely used to investigate gene regulation, bacterial susceptibility to antibiotics, host-pathogen interactions, and pathogenesis. Transcriptomics is crucially dependent on suitable methods to isolate and detect bacterial RNA. Microfluidics offer ways of creating integrated point-of-care systems, analysing a sample from preparation, and RNA isolation to detection. A critical requirement for on-chip diagnostics to deliver on their promise is that mRNA expression is not altered via microfluidic sample processing. This article investigates the impact of the use of microfluidics upon RNA expression of bacteria isolated from blood, a key step towards proving the suitability of such systems for further development.

Identifiers

PMID26045727
PMCPMC4449352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.