ArticleAJNR. American journal of neuroradiology2015
MR Elastography Can Be Used to Measure Brain Stiffness Changes as a Result of Altered Cranial Venous Drainage During Jugular Compression.
Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 63 citations in OpenAlex.
- Influence of a neck compression collar on cerebrovascular and autonomic function in men and women.PloS one · 2019Trial
- Analysis of head impact exposure and brain microstructure response in a season-long application of a jugular vein compression collar: a prospective, neuroimaging investigation in American football.British journal of sports medicine · 2016Trial
- Article
- Effects and Correction of Patient Bulk Motion in Cranial DENSE MRI.Magnetic resonance in medicine · 2026Article
- A novel method of fabricating dynamic, heterogenous benchtop lateral and third ventricle phantoms from MRI of hydrocephalus patients: a verification and validation study.Fluids and barriers of the CNS · 2026Article
- Anatomical Reasons for an Impaired Internal Jugular Flow.Medicina (Kaunas, Lithuania) · 2025Review
- Acute effects of high-intensity exercise on brain mechanical properties and cognitive function.Brain imaging and behavior · 2024Article
- The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- A transvenous pressure gradient can explain the MR elastography findings in normal pressure hydrocephalus.Neurosurgical review · 2022Article
- Reply: A transvenous pressure gradient can explain the MR elastography findings in normal pressure hydrocephalus.Neurosurgical review · 2022Article
- Features of Idiopathic Intracranial Hypertension on MRI With MR Elastography: Prospective Comparison With Control Individuals and Assessment of Postintervention Changes.AJR. American journal of roentgenology · 2022Article
- Cerebrospinal fluid dynamics coupled to the global circulation in holistic setting: Mathematical models, numerical methods and applications.International journal for numerical methods in biomedical engineering · 2022Article
- Cerebral tomoelastography based on multifrequency MR elastography in two and three dimensions.Frontiers in bioengineering and biotechnology · 2022Article
- Brain stiffness following recovery in a patient with an episode of low-pressure hydrocephalus: case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Harnessing brain waves: a review of brain magnetic resonance elastography for clinicians and scientists entering the field.The British journal of radiology · 2021Review
- Real-Time Multifrequency MR Elastography of the Human Brain Reveals Rapid Changes in Viscoelasticity in Response to the Valsalva Maneuver.Frontiers in bioengineering and biotechnology · 2021Article
- Standard-space atlas of the viscoelastic properties of the human brain.Human brain mapping · 2020Article
- Cardiac-gated steady-state multifrequency magnetic resonance elastography of the brain: Effect of cerebral arterial pulsation on brain viscoelasticity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Cerebral Vessels: An Overview of Anatomy, Physiology, and Role in the Drainage of Fluids and Solutes.Frontiers in neurology · 2020Review
- Hypercapnia increases brain viscoelasticity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
background and purposeCompressing the internal jugular veins can reverse ventriculomegaly in the syndrome of inappropriately low pressure acute hydrocephalus, and it has been suggested that this works by "stiffening" the brain tissue. Jugular compression may also alter blood and CSF flow in other conditions. We aimed to understand the effect of jugular compression on brain tissue stiffness and CSF flow. MATERIALS AND
methodsThe head and neck of 9 healthy volunteers were studied with and without jugular compression. Brain stiffness (shear modulus) was measured by using MR elastography. Phase-contrast MR imaging was used to measure CSF flow in the cerebral aqueduct and blood flow in the neck.
resultsThe shear moduli of the brain tissue increased with the percentage of blood draining through the internal jugular veins during venous compression. Peak velocity of caudally directed CSF in the aqueduct increased significantly with jugular compression (P < .001). The mean jugular venous flow rate, amplitude, and vessel area were significantly reduced with jugular compression, while cranial arterial flow parameters were unaffected.
conclusionsJugular compression influences cerebral CSF hydrodynamics in healthy subjects and can increase brain tissue stiffness, but the magnitude of the stiffening depends on the percentage of cranial blood draining through the internal jugular veins during compression—that is, subjects who maintain venous drainage through the internal jugular veins during jugular compression have stiffer brains than those who divert venous blood through alternative pathways. These methods may be useful for studying this phenomenon in patients with the syndrome of inappropriately low-pressure acute hydrocephalus and other conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.