Trial reportAmerican journal of hypertension2016
Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature.
Trial report in American journal of hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic and Environmental Determinants of Triglycerides (GOLDN)
The Boston Puerto Rican Health Study: Center for Population Health and Health Disparities
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Ambient Temperature and Cardiac Biomarkers: A Meta-Analysis.Current cardiology reviews · 2023Pooled it
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- Perturbation of the circadian clock in chronic diseases involving organ fibrosis.The Journal of clinical investigation · 2025Review
- Association between weekday sleep, weekday-weekend sleep duration gap, and hypertension in American adolescents: a nationwide cross-sectional study.Frontiers in psychiatry · 2024Article
- Preliminary Study on the Effect of a Night Shift on Blood Pressure and Clock Gene Expression.International journal of molecular sciences · 2023Article
- Circadian rhythms and renal pathophysiology.The Journal of clinical investigation · 2022Review
- Sleep Duration and Hypertension: Epidemiological Evidence and Underlying Mechanisms.American journal of hypertension · 2022Review
- Aging disrupts the temporal organization of antioxidant defenses in the heart of male rats and phase shifts circadian rhythms of systolic blood pressure.Biogerontology · 2021Article
- Identification of Clock Genes Related to Hypertension in Kidney From Spontaneously Hypertensive Rats.American journal of hypertension · 2020Article
- Circadian rhythms and the molecular clock in cardiovascular biology and disease.Nature reviews. Cardiology · 2019Review
- Circadian rhythms and the kidney.Nature reviews. Nephrology · 2018Review
- Circadian clock-mediated regulation of blood pressure.Free radical biology & medicine · 2018Review
- Role of circadian gene Clock during differentiation of mouse pluripotent stem cells.Protein & cell · 2016Article
- Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans.Advances in nutrition (Bethesda, Md.) · 2016Review
- Nutrigenetics and Nutrimiromics of the Circadian System: The Time for Human Health.International journal of molecular sciences · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundDiurnal variation in blood pressure (BP) is regulated, in part, by an endogenous circadian clock; however, few human studies have identified associations between clock genes and BP. Accounting for environmental temperature may be necessary to correct for seasonal bias.
methodsWe examined whether environmental temperature on the day of participants' assessment was associated with BP, using adjusted linear regression models in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) (n = 819) and the Boston Puerto Rican Health Study (BPRHS) (n = 1,248) cohorts. We estimated phenotypic variance in BP by 18 clock genes and examined individual single-nucleotide polymorphism (SNP) associations with BP using an additive genetic model, with further consideration of environmental temperature.
resultsIn GOLDN, each additional 1 °C increase in environmental temperature was associated with 0.18 mm Hg lower systolic BP [SBP; β ± SE = -0.18 ± 0.05 mm Hg; P = 0.0001] and 0.10mm Hg lower diastolic BP [DBP; -0.10 ± 0.03 mm Hg; P = 0.001]. Similar results were seen in the BPRHS for SBP only. Clock genes explained a statistically significant proportion of the variance in SBP [V G/V P ± SE = 0.071 ± 0.03; P = 0.001] in GOLDN, but not in the BPRHS, and we did not observe associations between individual SNPs and BP. Environmental temperature did not influence the identified genetic associations.
conclusionsWe identified clock genes that explained a statistically significant proportion of the phenotypic variance in SBP, supporting the importance of the circadian pathway underlying cardiac physiology. Although temperature was associated with BP, it did not affect results with genetic markers in either study. Therefore, it does not appear that temperature measures are necessary for interpreting associations between clock genes and BP. CLINICAL
trial registrationTrials related to this study were registered at clinicaltrials.gov as NCT00083369 (Genetic and Environmental Determinants of Triglycerides) and NCT01231958 (Boston Puerto Rican Health Study).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.