Evidence map›Paper›PMID 26045531›Full record

ArticleAmerican journal of hypertension2016

Correlates of Segmental Pulse Wave Velocity in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study.

Michelle L Meyer, Hirofumi Tanaka, Priya Palta, Susan Cheng, Natalia Gouskova, David Aguilar, Gerardo Heiss

Abstract readMulticenter Study
In one paragraph

Article in American journal of hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Comparative prognostic value of non-invasive ventricular-arterial coupling metrics in the general population.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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  8. Association of central arterial stiffness with atrial myopathy: the Atherosclerosis Risk in Communities (ARIC) study.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michelle L MeyerDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; mlmeyer@unc.edu.
Hirofumi TanakaDepartment of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas, USA;
Priya PaltaDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA;
Susan ChengCardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA;
Natalia GouskovaDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA;
David AguilarDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Gerardo HeissDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA;

Funding

Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0M
Myocardial and Arterial Aging: Spectrum, Correlates, and PrognosisR00HL107642 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHENG, SUSAN · 2014 to 2016
$747k
NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS R00 HL107642NHLBI NIH HHS T32 HL007055
6 · The paper itself

Abstract

backgroundCarotid-femoral PWV (cfPWV) is a well-established measure of central arterial stiffness, while brachial-ankle PWV (baPWV) is being used more frequently in East Asian countries. Few studies have simultaneously characterized the distributions and correlates of segment-specific PWV measures and their associations with cardiovascular risk factors.

methodsWe evaluated segment-specific PWV (cfPWV, baPWV, and femoral-ankle (faPWV)) in 4,974 older-aged African American and Caucasian adults in the community-based Atherosclerosis Risk in Communities (ARIC) Study using a standardized protocol and the OMRON VP-1000 Plus system. We examined the distribution and multivariable-adjusted correlates of PWV measures by race and sex.

resultsMean age ranged from 74 ± 5 to 76 ± 5 years across race-sex groups. In all race-sex groups, cfPWV correlated with baPWV but not with faPWV, and cfPWV and baPWV were higher with age, whereas faPWV was not. Heart rate and systolic blood pressure (SBP) were positively associated and weight was negatively associated with all PWV measures; however, the associations with age, glycated hemoglobin, triglycerides, and high-density lipoprotein (HDL) cholesterol varied by segment and race-sex group.

conclusionsOur findings indicate that cfPWV and faPWV reflect distinct aspects of segment-specific vascular stiffness and their associated profile of cardiovascular risk factors. Even among older adults, age is associated with higher cfPWV and baPWV, but not with faPWV. Understanding factors that ostensibly play a role in increasing arterial stiffness in different arterial territories can inform opportunities for cardiovascular disease (CVD) prevention and risk management.

Indexed as

AgedAnkle Brachial IndexAtherosclerosisBlack or African AmericanBlood PressureBrachial ArteryCarotid ArteriesFemaleFemoral ArteryFollow-Up StudiesHumansIncidenceMaleMiddle AgedPulsatile FlowPulse Wave Analysisarterial stiffnessarteriosclerosisatherosclerosisblood pressurecardiovascular disease risk factorselastic arteryepidemiologyhypertensionmuscular arterysubclinical cardiovascular diseasevascular stiffness.

Identifiers

PMID26045531
PMCPMC4692984

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.