Evidence map›Paper›PMID 26045351›Full record

SynthesisThe British journal of psychiatry : the journal of mental science2015

Neuroimaging distinction between neurological and psychiatric disorders.

Nicolas A Crossley, Jessica Scott, Ian Ellison-Wright, Andrea Mechelli

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The British journal of psychiatry : the journal of mental science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. Review
  9. Palliative psychiatry in a narrow and in a broad sense: A concept clarification.The Australian and New Zealand journal of psychiatry · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Nicolas A CrossleyNicolas A. Crossley, MRCPsych, PhD, Jessica Scott, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London; Ian Ellison-Wright, MRCPsych, Avon and Wiltshire Mental Health Partnership NHS Trust, Salisbury; Andrea Mechelli, PhD, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK.
Jessica ScottNicolas A. Crossley, MRCPsych, PhD, Jessica Scott, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London; Ian Ellison-Wright, MRCPsych, Avon and Wiltshire Mental Health Partnership NHS Trust, Salisbury; Andrea Mechelli, PhD, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK.
Ian Ellison-WrightNicolas A. Crossley, MRCPsych, PhD, Jessica Scott, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London; Ian Ellison-Wright, MRCPsych, Avon and Wiltshire Mental Health Partnership NHS Trust, Salisbury; Andrea Mechelli, PhD, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK.
Andrea MechelliNicolas A. Crossley, MRCPsych, PhD, Jessica Scott, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London; Ian Ellison-Wright, MRCPsych, Avon and Wiltshire Mental Health Partnership NHS Trust, Salisbury; Andrea Mechelli, PhD, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK a.mechelli@kcl.ac.uk.

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
Medical Research Council 99859Medical Research Council G1100574NIMH NIH HHS R01 MH074457Wellcome TrustWellcome Trust WT093907
6 · The paper itself

Abstract

backgroundIt is unclear to what extent the traditional distinction between neurological and psychiatric disorders reflects biological differences.

aimsTo examine neuroimaging evidence for the distinction between neurological and psychiatric disorders.

methodWe performed an activation likelihood estimation meta-analysis on voxel-based morphometry studies reporting decreased grey matter in 14 neurological and 10 psychiatric disorders, and compared the regional and network-level alterations for these two classes of disease. In addition, we estimated neuroanatomical heterogeneity within and between the two classes.

resultsBasal ganglia, insula, sensorimotor and temporal cortex showed greater impairment in neurological disorders; whereas cingulate, medial frontal, superior frontal and occipital cortex showed greater impairment in psychiatric disorders. The two classes of disorders affected distinct functional networks. Similarity within classes was higher than between classes; furthermore, similarity within class was higher for neurological than psychiatric disorders.

conclusionsFrom a neuroimaging perspective, neurological and psychiatric disorders represent two distinct classes of disorders.

Indexed as

NeuroimagingBrain MappingGray MatterHumansLikelihood FunctionsMagnetic Resonance ImagingMental DisordersNervous System DiseasesTemporal Lobe

Identifiers

PMID26045351
PMCPMC4629073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.